Evolution and diversity of nucleotide and dinucleotide composition in poxviruses

C Molteni, D Forni, R Cagliani… - Journal of General …, 2023 - microbiologyresearch.org
Poxviruses (family Poxviridae) have long dsDNA genomes and infect a wide range of hosts,
including insects, birds, reptiles and mammals. These viruses have substantial incidence …

[HTML][HTML] Translation of the downstream ORF from bicistronic mRNAs by human cells: Impact of codon usage and splicing in the upstream ORF

P Paget‐Bailly, A Helpiquet… - Protein Science: A …, 2025 - pmc.ncbi.nlm.nih.gov
Biochemistry textbooks describe eukaryotic mRNAs as monocistronic. However, increasing
evidence reveals the widespread presence and translation of upstream open reading …

Pervasive translation of the downstream ORF from bicistronic mRNAs by human cells: impact of the upstream ORF codon usage and splicing

P Paget-Bailly, A Helpiquet, M Decourcelle, R Bories… - bioRxiv, 2024 - biorxiv.org
In this work, we present a straightforward model to study gene expression regulation from
virus-like bicistronic mRNAs in human cells, composed by a short shble upstream ORF and …

[HTML][HTML] Effect of mRNA/tRNA mutations on translation speed: Implications for human diseases

M Davyt, N Bharti, Z Ignatova - Journal of Biological Chemistry, 2023 - Elsevier
Recent discoveries establish tRNAs as central regulators of mRNA translation dynamics,
and therefore cotranslational folding and function of the encoded protein. The tRNA pool …

Subfunctionalisation of paralogous genes and evolution of differential codon usage preferences: The showcase of polypyrimidine tract binding proteins

J Bourret, F Borvető, IG Bravo - Journal of Evolutionary Biology, 2023 - academic.oup.com
Gene paralogs are copies of an ancestral gene that appear after gene or full genome
duplication. When two sister gene copies are maintained in the genome, redundancy may …