A functional, replete T-cell repertoire is an integral component to adequate immune
surveillance and to the initiation and maintenance of productive antitumor immune …

Over the past decade, our understanding of cancer immunotherapy has evolved from
assessing peripheral responses in the blood to monitoring changes in the tumour …

Characterizing the transcriptome of individual cells is fundamental to understanding
complex biological systems. We describe a droplet-based system that enables 3′ mRNA …

Microglia, the parenchymal brain macrophages of the central nervous system, have
emerged as critical players in brain development and homeostasis. The immune functions of …

Importance Neuroinflammation appears to be a key modulator of disease progression in
amyotrophic lateral sclerosis (ALS) and thereby a promising therapeutic target. The CD4+ …

Regulatory T cells (Tregs) constitute a fascinating subpopulation of CD4+ T cells due to their
ability to limit the immune response against self and non-self antigens. Murine models and …

Regulatory T cells, a subpopulation of suppressive T cells, are potent mediators of self-
tolerance and essential for the suppression of triggered immune responses. The immune …

Plasmodium falciparum malaria drives immunoregulatory responses across multiple cell
subsets, which protects from immunopathogenesis, but also hampers the development of …

Regulatory T cells (Tregs) are comprised of a heterogeneous population of cells that play a
vital role in suppressing inflammation and maintaining immune tolerance. Given the crucial …

Gastric cancer (GC) is a highly aggressive malignancy that remains a significant contributor
to cancer-related mortality worldwide, despite a decline in incidence in recent years. Early …