MicroRNAs as therapeutic targets in cardiovascular disease
B Laggerbauer, S Engelhardt - The Journal of clinical …, 2022 - Am Soc Clin Investig
The discovery of microRNAs and their role in diseases was a breakthrough that inspired
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
research into microRNAs as drug targets. Cardiovascular diseases are an area in which …
MSC exosome works through a protein-based mechanism of action
Mesenchymal stem cell (MSC) exosome specifically defines the 50–200 nm vesicles that are
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
secreted into the extracellular space when multivesicular bodies in the MSC fuse with the …
Assessing the ceRNA hypothesis with quantitative measurements of miRNA and target abundance
Recent studies have reported that competitive endogenous RNAs (ceRNAs) can act as
sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA …
sponges for a microRNA (miRNA) through their binding sites and that changes in ceRNA …
Non-coding RNA: what is functional and what is junk?
AF Palazzo, ES Lee - Frontiers in genetics, 2015 - frontiersin.org
The genomes of large multicellular eukaryotes are mostly comprised of non-protein coding
DNA. Although there has been much agreement that a small fraction of these genomes has …
DNA. Although there has been much agreement that a small fraction of these genomes has …
Exogenous plant MIR168a specifically targets mammalian LDLRAP1: evidence of cross-kingdom regulation by microRNA
L Zhang, D Hou, X Chen, D Li, L Zhu, Y Zhang, J Li… - Cell research, 2012 - nature.com
Our previous studies have demonstrated that stable microRNAs (miRNAs) in mammalian
serum and plasma are actively secreted from tissues and cells and can serve as a novel …
serum and plasma are actively secreted from tissues and cells and can serve as a novel …
MicroRNAs in human cancer
Mature microRNAs (miRNAs) are single-stranded RNA molecules of 20–23-nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …
length that control gene expression in many cellular processes. These molecules typically …
Endogenous miRNA and target concentrations determine susceptibility to potential ceRNA competition
AD Bosson, JR Zamudio, PA Sharp - Molecular cell, 2014 - cell.com
Target competition (ceRNA crosstalk) within miRNA-regulated gene networks has been
proposed to influence biological systems. To assess target competition, we characterize and …
proposed to influence biological systems. To assess target competition, we characterize and …
Intracellular and extracellular microRNA: An update on localization and biological role
MicroRNA (miRNA) is a class of small non-coding RNAs which mediate post-transcriptional
gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or …
gene silencing (PTGS) by sequence-specific inhibition of target mRNAs translation and/or …
miRNAs in human cancer
TA Farazi, JI Spitzer, P Morozov… - The Journal of …, 2011 - Wiley Online Library
Mature microRNAs (miRNAs) are single‐stranded RNA molecules of 20–23 nucleotide (nt)
length that control gene expression in many cellular processes. These molecules typically …
length that control gene expression in many cellular processes. These molecules typically …
Rapid electronic detection of probe-specific microRNAs using thin nanopore sensors
Small RNA molecules have an important role in gene regulation and RNA silencing therapy,
but it is challenging to detect these molecules without the use of time-consuming radioactive …
but it is challenging to detect these molecules without the use of time-consuming radioactive …