Abstract Purpose of Review Apoptosis is a major mechanism of cancer cell death. Thus,
evasion of apoptosis results in therapy resistance. Here, we review apoptosis modulators in …

Introduction: Human cancers are genetically and epigenetically heterogeneous and have
the capacity to commandeer a variety of cellular processes to aid in their survival, growth …

The development of BH3 mimetics, which antagonize prosurvival proteins of the BCL-2
family, represents a potential breakthrough in cancer therapy. Targeting the prosurvival …

Introduction Effective therapies after failure of treatment with anthracyclines and taxanes are
needed for patients with metastatic breast cancer. Dinaciclib (MK-7965, formerly …

Outcomes have improved significantly for many women diagnosed with breast cancer. For
the heterogeneous group of tumours lacking expression of the oestrogen, progesterone and …

Apoptosis, cell death executed by caspases, is essential to normal breast development and
homeostasis. Pro-apoptotic and anti-apoptotic signals are tightly regulated in normal breast …

Evasion from apoptosis is an important hallmark of cancer cells. Alterations of apoptosis
pathways are especially critical as they confer resistance to conventional anti-cancer …

Breast cancer is the second-most frequently diagnosed malignancy in US women. The triple-
negative breast cancer (TNBC) subtype, which lacks expression of the estrogen receptor …

Triple negative breast cancers, which are defined by lack of expression of estrogen,
progesterone, or HER2 receptors, represent approximately 15% of all breast cancers …

An estimated 15–20% of breast cancers overexpress human epidermal growth factor
receptor 2 (HER2/ERBB2/neu). Two small-molecule tyrosine kinase inhibitors (TKIs) …