The protective role of estrogen and estrogen receptors in cardiovascular disease and the controversial use of estrogen therapy
Epidemiologic studies have previously suggested that premenopausal females have
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …
reduced incidence of cardiovascular disease (CVD) when compared to age-matched males …
[HTML][HTML] Cardiac fibrosis: new insights into the pathogenesis
ZG Ma, YP Yuan, HM Wu, X Zhang… - International journal of …, 2018 - ncbi.nlm.nih.gov
Cardiac fibrosis is defined as the imbalance of extracellular matrix (ECM) production and
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …
degradation, thus contributing to cardiac dysfunction in many cardiac pathophysiologic …
Specialized fibroblast differentiated states underlie scar formation in the infarcted mouse heart
Fibroblasts are a dynamic cell type that achieve selective differentiated states to mediate
acute wound healing and long-term tissue remodeling with scarring. With myocardial …
acute wound healing and long-term tissue remodeling with scarring. With myocardial …
Molecular distinction between physiological and pathological cardiac hypertrophy: experimental findings and therapeutic strategies
Cardiac hypertrophy can be defined as an increase in heart mass. Pathological cardiac
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
hypertrophy (heart growth that occurs in settings of disease, eg hypertension) is a key risk …
Cardiac fibroblast: the renaissance cell
CA Souders, SLK Bowers, TA Baudino - Circulation research, 2009 - Am Heart Assoc
The permanent cellular constituents of the heart include cardiac fibroblasts, myocytes,
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …
endothelial cells, and vascular smooth muscle cells. Previous studies have demonstrated …
Developmental heterogeneity of cardiac fibroblasts does not predict pathological proliferation and activation
Rationale: Fibrosis is mediated partly by extracellular matrix–depositing fibroblasts in the
heart. Although these mesenchymal cells are reported to have multiple embryonic origins …
heart. Although these mesenchymal cells are reported to have multiple embryonic origins …
IL-33 and ST2 comprise a critical biomechanically induced and cardioprotective signaling system
S Sanada, D Hakuno, LJ Higgins… - The Journal of …, 2007 - Am Soc Clin Investig
ST2 is an IL-1 receptor family member with transmembrane (ST2L) and soluble (sST2)
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …
isoforms. sST2 is a mechanically induced cardiomyocyte protein, and serum sST2 levels …
The IL-33/ST2 pathway: therapeutic target and novel biomarker
For many years, the interleukin-1 receptor family member ST2 was an orphan receptor that
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …
was studied in the context of inflammatory and autoimmune disease. However, in 2005, a …
The fibrosis marker galectin‐3 and outcome in the general population
RA De Boer, DJ Van Veldhuisen… - Journal of internal …, 2012 - Wiley Online Library
de Boer RA, van Veldhuisen DJ, Gansevoort RT, Muller Kobold AC, van Gilst WH, Hillege
HL, Bakker SJL, van der Harst P (University of Groningen). The fibrosis marker galectin‐3 …
HL, Bakker SJL, van der Harst P (University of Groningen). The fibrosis marker galectin‐3 …
Cardiac fibrosis and arrhythmogenesis: the road to repair is paved with perils
In the healthy heart, cardiac myocytes form an electrical syncytium embedded in a
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …
supportive fibroblast-rich extracellular matrix designed to optimize the electromechanical …