Implants with sensing capabilities

M Veletic, EH Apu, M Simic, J Bergsland… - Chemical …, 2022 - ACS Publications
Because of the aging human population and increased numbers of surgical procedures
being performed, there is a growing number of biomedical devices being implanted each …

Adaptive deep brain stimulation: From experimental evidence toward practical implementation

WJ Neumann, R Gilron, S Little… - Movement …, 2023 - Wiley Online Library
Closed‐loop adaptive deep brain stimulation (aDBS) can deliver individualized therapy at
an unprecedented temporal precision for neurological disorders. This has the potential to …

Chronic adaptive deep brain stimulation versus conventional stimulation in Parkinson's disease: a blinded randomized feasibility trial

CR Oehrn, S Cernera, LH Hammer, M Shcherbakova… - Nature Medicine, 2024 - nature.com
Deep brain stimulation (DBS) is a widely used therapy for Parkinson's disease (PD) but
lacks dynamic responsiveness to changing clinical and neural states. Feedback control …

Insights and opportunities for deep brain stimulation as a brain circuit intervention

WJ Neumann, A Horn, AA Kühn - Trends in Neurosciences, 2023 - cell.com
Deep brain stimulation (DBS) is an effective treatment and has provided unique insights into
the dynamic circuit architecture of brain disorders. This Review illustrates our current …

Towards adaptive deep brain stimulation: clinical and technical notes on a novel commercial device for chronic brain sensing

Y Thenaisie, C Palmisano, A Canessa… - Journal of Neural …, 2021 - iopscience.iop.org
Objective. Technical advances in deep brain stimulation (DBS) are crucial to improve
therapeutic efficacy and battery life. We report the potentialities and pitfalls of one of the first …

A systematic review of local field potential physiomarkers in Parkinson's disease: from clinical correlations to adaptive deep brain stimulation algorithms

BCM van Wijk, RMA de Bie, M Beudel - Journal of neurology, 2023 - Springer
Deep brain stimulation (DBS) treatment has proven effective in suppressing symptoms of
rigidity, bradykinesia, and tremor in Parkinson's disease. Still, patients may suffer from …

[HTML][HTML] Clinical neurophysiology of Parkinson's disease and parkinsonism

R Chen, A Berardelli, A Bhattacharya… - Clinical neurophysiology …, 2022 - Elsevier
This review is part of the series on the clinical neurophysiology of movement disorders. It
focuses on Parkinson's disease and parkinsonism. The topics covered include the …

Diurnal modulation of subthalamic beta oscillatory power in Parkinson's disease patients during deep brain stimulation

JJ van Rheede, LK Feldmann, JL Busch… - npj Parkinson's …, 2022 - nature.com
Beta-band activity in the subthalamic local field potential (LFP) is correlated with Parkinson's
disease (PD) symptom severity and is the therapeutic target of deep brain stimulation (DBS) …

Multi-night cortico-basal recordings reveal mechanisms of NREM slow-wave suppression and spontaneous awakenings in Parkinson's disease

MF Anjum, C Smyth, R Zuzuárregui, DJ Dijk… - Nature …, 2024 - nature.com
Sleep disturbance is a prevalent and disabling comorbidity in Parkinson's disease (PD). We
performed multi-night (n= 57) at-home intracranial recordings from electrocorticography and …

On closed-loop brain stimulation systems for improving the quality of life of patients with neurological disorders

AN Belkacem, N Jamil, S Khalid… - Frontiers in human …, 2023 - frontiersin.org
Emerging brain technologies have significantly transformed human life in recent decades.
For instance, the closed-loop brain-computer interface (BCI) is an advanced software …