The effects of early life stress on the epigenome: from the womb to adulthood and even before
N Provençal, EB Binder - Experimental neurology, 2015 - Elsevier
Exposure to early life stress (ELS), such as childhood abuse and neglect is a well
established major risk factor for developing psychiatric and behavioral disorders later in life …
established major risk factor for developing psychiatric and behavioral disorders later in life …
Steroid up-regulation of FKBP51 and its role in hormone signaling
T Jääskeläinen, H Makkonen, JJ Palvimo - Current opinion in …, 2011 - Elsevier
FK506 binding protein 51 (FKBP51, FKBP5) functions as a co-chaperone for androgen,
glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an …
glucocorticoid, mineralocorticoid and progesterone receptors. The FKBP51 can act as an …
Discovery of non-ETS gene fusions in human prostate cancer using next-generation RNA sequencing
Half of prostate cancers harbor gene fusions between TMPRSS2 and members of the ETS
transcription factor family. To date, little is known about the presence of non-ETS fusion …
transcription factor family. To date, little is known about the presence of non-ETS fusion …
Determinants of receptor-and tissue-specific actions in androgen signaling
The physiological androgens testosterone and 5α-dihydrotestosterone regulate the
development and maintenance of primary and secondary male sexual characteristics …
development and maintenance of primary and secondary male sexual characteristics …
Glucocorticoid Receptor Activates Poised FKBP51 Locus through Long-Distance Interactions
V Paakinaho, H Makkonen… - Molecular …, 2010 - academic.oup.com
Recent studies have identified FKBP51 (FK506-binding protein 51) as a sensitive biomarker
of corticosteroid responsiveness in vivo. In this work, we have elucidated the molecular …
of corticosteroid responsiveness in vivo. In this work, we have elucidated the molecular …
The role of FKBP5 in cancer aetiology and chemoresistance
L Li, Z Lou, L Wang - British journal of cancer, 2011 - nature.com
Abstract FK506 binding protein 51 (FKBP51, also called FKBP5) belongs to a family of
immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs …
immunophilins, FK506 binding proteins (FKBPs). Members of this family are targets for drugs …
Paxillin mediates extranuclear and intranuclear signaling in prostate cancer proliferation
A Sen, I De Castro, DB DeFranco… - The Journal of …, 2012 - Am Soc Clin Investig
In prostate cancer, the signals that drive cell proliferation change as tumors progress from
castration-sensitive (androgen-dominant) to castration-resistant states. While the …
castration-sensitive (androgen-dominant) to castration-resistant states. While the …
FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A
Prostate cancer (PCa) growth is dependent on androgens and on the androgen receptor
(AR), which acts by modulating gene transcription. Tetratricopeptide repeat (TPR) proteins …
(AR), which acts by modulating gene transcription. Tetratricopeptide repeat (TPR) proteins …
Androgen regulation of gene expression
KR Lamont, DJ Tindall - Advances in cancer research, 2010 - Elsevier
The biological action of androgenic male sex steroid hormones in prostate tissue is
mediated by the androgen receptor, a nuclear transcription factor. The transcriptional …
mediated by the androgen receptor, a nuclear transcription factor. The transcriptional …
Selective roles for cAMP response element-binding protein binding protein and p300 protein as coregulators for androgen-regulated gene expression in advanced …
I Ianculescu, DY Wu, KD Siegmund… - Journal of Biological …, 2012 - ASBMB
The protein acetyltransferases p300 and cAMP response element-binding protein binding
protein (CBP) are homologous, ubiquitously expressed proteins that interact with hundreds …
protein (CBP) are homologous, ubiquitously expressed proteins that interact with hundreds …