The radical SAM enzymes—also referred to as the AdoMet radical enzymes—are a newly
identified enzyme superfamily1 capable of catalyzing radical chemistry similar to, but more …

Methylation of biomolecules is a frequent biochemical reaction within the cell, and a plethora
of highly specific methyltransferases (MTases) catalyse the transfer of a methyl group from S …

Increased protein synthesis plays an etiologic role in diverse cancers. Here, we demonstrate
that METTL13 (methyltransferase-like 13) dimethylation of eEF1A (eukaryotic elongation …

Abstract Background The genome of Helicobacter pylori, an oncogenic bacterium in the
human stomach, rapidly evolves and shows wide geographical divergence. The high …

Methylation is one of the most common protein modifications. Many different prokaryotic and
eukaryotic proteins are methylated, including proteins involved in translation, including …

Lysine methylation is an abundant posttranslational modification, which has been most
intensively studied in the context of histone proteins, where it represents an important …

A number of ribosomal proteins in Escherichia coli undergo posttranslational modifications.
Six ribosomal proteins are methylated (S11, L3, L11, L7/L12, L16, and L33), three proteins …

Many cellular proteins are methylated on lysine residues and this has been most intensively
studied for histone proteins. Lysine methylations on non-histone proteins are also frequent …

Among the 22 proteinogenic amino acids, lysine sticks out due to its unparalleled chemical
diversity of post-translational modifications. This results in a wide range of possibilities to …

Mitochondria are responsible for the production of over 90% of the energy in eukaryotes
through oxidative phosphorylation performed by electron transfer and ATP synthase …