Age-related macular degeneration (AMD) was described for the first time in the 1840s and is
currently the leading cause of blindness for patients over 65 years in Western Countries …

Lipid metabolic abnormalities have emerged as potential risk factors for the development
and progression of diabetic complications, including diabetic retinopathy (DR). This review …

The recent unprecedented progress in ageing research and drug discovery brings together
fundamental research and clinical applications to advance the goal of promoting healthy …

The enzyme soluble epoxide hydrolase (sEH) plays a central role in metabolism of bioactive
lipid signaling molecules. The substrate-specific hydrolase activity of sEH converts …

Age-related macular degeneration (AMD) is a blinding eye disease, whose incidence
strongly increases with ages. The etiology of AMD is complex, including aging, abnormal …

Over the last decade, cases of metabolic syndrome and type II diabetes have increased
exponentially. Exercise and ω-3 polyunsaturated fatty acid (PUFA)-enriched diets are …

Ferrochelatase (FECH) is the terminal enzyme in heme biosynthesis. We previously showed
that FECH is required for endothelial cell growth in vitro and choroidal neovascularization in …

Under healthy conditions, the cornea is an avascular structure which allows for transparency
and optimal visual acuity. Its avascular nature is maintained by a balance of proangiogenic …

Chemical proteomics using biotin probes of natural products have significantly advanced
our understanding of molecular targets and therapeutic potential. This review highlights …

Polyunsaturated fatty acids such as docosahexaenoic acid (DHA) positively affect the
outcome of retinopathy of prematurity (ROP). Given that DHA metabolism by cytochrome …