Although procoagulant TF is clearly expressed in the vascular subendothelium, it has also
been proposed that many different cell types express an inactive, encrypted form of TF that …

Krüppel-like factors (KLFs) are a family of transcription factors characterised by zinc-finger
structures at the C-terminal. They play the key roles in cell proliferation, differentiation, and …

BACKGROUND: Hyperglycemia—a symptom that characterizes diabetes—is highly
associated with atherothrombotic complications. However, the underlying mechanism by …

Abdominal aortic aneurysm (AAA) is a life-threatening degenerative vascular disease.
Endothelial cell (EC) dysfunction is implicated in AAA. Our group recently demonstrated that …

Background Atherosclerotic cardiovascular diseases remain the leading cause of mortality
in diabetic patients, with endothelial cell (EC) dysfunction serving as the initiating step of …

Ferroptosis is a form of cell death and has great potential application in the treatment of
many cancers, including clear cell renal cell carcinoma (ccRCC). Herein, we identified the …

Proprotein convertase subtilisin/kexins (PCSKs) constitute a family of nine related proteases:
PCSK1-7, MBTPS1, and PCSK9. Apart from PCSK9, little is known about PCSKs in …

Scope Phytosterols (PS) and sterol oxidation products are key dietary factors influencing
atherosclerosis besides cholesterol, although the mechanisms remain elusive. Recently …

Microvascular endothelial cell (EC) injury and the subsequent blood‐brain barrier (BBB)
breakdown are frequently seen in many neurological disorders, including stroke. We have …

Progression of virtually all forms of chronic kidney disease (CKD) is associated with
activation of pro-inflammatory and pro-fibrotic signaling pathways. Despite extensive …