Hematopoiesis is a complex process with a variety of different signaling pathways
influencing every step of blood cell formation from the earliest precursors to final …

The zebrafish (Danio rerio) has been extensively used in biomedical research as a model to
study vertebrate development and hematopoiesis and recently, it has been adopted into …

Macrophages and neutrophils play important roles during the innate immune response,
phagocytosing invading microbes and delivering antimicrobial compounds to the site of …

Background How different immune cell compartments contribute to a successful immune
response is central to fully understanding the mechanisms behind normal processes such …

Blood cells are constantly produced in the bone marrow (BM) of adult mammals. This
constant turnover ultimately depends on a rare population of progenitors that displays self …

Fibroblast growth factor (FGF) signalling has been implicated during several phases of early
embryogenesis, including the patterning of the embryonic axes, the induction and/or …

Progressive advances using zebrafish as a model organism have provided hematologists
with an additional genetic system to study blood cell formation and hematological …

The first leukocytes that arise in the development of vertebrate embryos are the primitive
macrophages, which differentiate in the yolk sac and then quickly invade embryonic tissues …

Background: Macrophages and neutrophils are key phagocytes in regeneration. Results:
Neutrophils are the primary phagocytes in the inflammatory stage and are dispensable for …

The zebrafish is a powerful model system for investigating embryonic vertebrate
hematopoiesis, allowing for the critical in vivo analysis of cell lineage determination. In this …