Cerebral oxygen extraction fraction MRI: Techniques and applications
The human brain constitutes 2% of the body's total mass but uses 20% of the oxygen. The
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …
rate of the brain's oxygen utilization can be derived from a knowledge of cerebral blood flow …
[HTML][HTML] Non-contrast assessment of blood-brain barrier permeability to water in mice: An arterial spin labeling study at cerebral veins
Blood-brain barrier (BBB) plays a critical role in protecting the brain from toxins and
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
pathogens. However, in vivo tools to assess BBB permeability are scarce and often require …
The impact of isoflurane anesthesia on brain metabolism in mice: An MRI and electroencephalography study
Isoflurane is one of the most widely used anesthetic agents in rodent imaging studies.
However, the impact of isoflurane on brain metabolism has not been fully characterized to …
However, the impact of isoflurane on brain metabolism has not been fully characterized to …
High-resolution relaxometry-based calibrated fMRI in murine brain: Metabolic differences between awake and anesthetized states
M Xu, B Bo, M Pei, Y Chen, CY Shu… - Journal of Cerebral …, 2022 - journals.sagepub.com
Functional magnetic resonance imaging (fMRI) techniques using the blood-oxygen level-
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …
dependent (BOLD) signal have shown great potential as clinical biomarkers of disease …
Metabolic and vascular imaging markers for investigating Alzheimer's disease complicated by sleep fragmentation in mice
Background Sleep problem is a common complication of Alzheimer's disease (AD).
Extensive preclinical studies have been performed to investigate the AD pathology …
Extensive preclinical studies have been performed to investigate the AD pathology …
Brain oximetry and the quest for quantified metabolic rate: applications using MRI and near-infrared spectroscopy
Cerebral metabolic rate of oxygen (CMRO2) is a robust marker of brain health. It represents
the amount of oxygen consumed by the brain, and it has been proved to be more sensitive …
the amount of oxygen consumed by the brain, and it has been proved to be more sensitive …
[HTML][HTML] Senolytic therapy preserves blood-brain barrier integrity and promotes microglia homeostasis in a tauopathy model
M Yao, Z Wei, JS Nielsen, Y Ouyang, A Kakazu… - Neurobiology of …, 2024 - Elsevier
Cellular senescence, characterized by expressing the cell cycle inhibitory proteins, is
evident in driving age-related diseases. Senescent cells play a crucial role in the initiation …
evident in driving age-related diseases. Senescent cells play a crucial role in the initiation …
Brain metabolism in tau and amyloid mouse models of Alzheimer's disease: An MRI study
Alzheimer's disease (AD) is the leading cause of cognitive impairment and dementia in
elderly individuals. According to the current biomarker framework for “unbiased descriptive …
elderly individuals. According to the current biomarker framework for “unbiased descriptive …
Age-related alterations in brain perfusion, venous oxygenation, and oxygen metabolic rate of mice: a 17-month longitudinal MRI study
Background: Characterization of physiological parameters of the aging brain, such as
perfusion and brain metabolism, is important for understanding brain function and diseases …
perfusion and brain metabolism, is important for understanding brain function and diseases …
Toward accurate cerebral blood flow estimation in mice after accounting for anesthesia
Purpose: To improve the accuracy of cerebral blood flow (CBF) measurement in mice by
accounting for the anesthesia effects. Methods: The dependence of CBF on anesthesia dose …
accounting for the anesthesia effects. Methods: The dependence of CBF on anesthesia dose …