The complex biology of human cytomegalovirus latency

F Goodrum - Advances in virus research, 2022 - Elsevier
While many viral infections are limited and eventually resolved by the host immune
response or by death of the host, other viruses establish long-term relationships with the …

NAT10-dependent N4‐acetylcytidine modification mediates PAN RNA stability, KSHV reactivation, and IFI16-related inflammasome activation

Q Yan, J Zhou, Z Wang, X Ding, X Ma, W Li… - Nature …, 2023 - nature.com
Abstract N-acetyltransferase 10 (NAT10) is an N 4‐acetylcytidine (ac4C) writer that catalyzes
RNA acetylation at cytidine N4 position on tRNAs, rRNAs and mRNAs. Recently, NAT10 and …

Role of virus-induced host cell epigenetic changes in cancer

V Pietropaolo, C Prezioso, U Moens - International Journal of Molecular …, 2021 - mdpi.com
The tumor viruses human T-lymphotropic virus 1 (HTLV-1), hepatitis C virus (HCV), Merkel
cell polyomavirus (MCPyV), high-risk human papillomaviruses (HR-HPVs), Epstein-Barr …

Phase separation and DAXX redistribution contribute to LANA nuclear body and KSHV genome dynamics during latency and reactivation

O Vladimirova, A De Leo, Z Deng, A Wiedmer… - PLoS …, 2021 - journals.plos.org
Liquid-liquid phase separation (LLPS) can drive formation of diverse and essential
macromolecular structures, including those specified by viruses. Kaposi's Sarcoma …

KSHV topologically associating domains in latent and reactivated viral chromatin

M Campbell, C Chantarasrivong… - Journal of …, 2022 - Am Soc Microbiol
Eukaryotic genomes are structurally organized via the formation of multiple loops that create
gene expression regulatory units called topologically associating domains (TADs). Here we …

[HTML][HTML] EZH2 Inhibition by DS3201 Triggers the Kaposi's Sarcoma-Associated Herpesvirus Lytic Cycle and Potentiates the Effects Induced by SAHA in Primary …

R Gonnella, F Collura, V Corrado, M Di Crosta… - Viruses, 2024 - mdpi.com
Primary Effusion Lymphoma (PEL) cells carry Kaposi's sarcoma-associated herpesvirus
(KSHV) in a latent state, except for a small number of cells in which the virus replicates to …

Utilization of host cell chromosome conformation by viral pathogens: knowing when to hold and when to fold

K Majumder, AJ Morales - Frontiers in immunology, 2021 - frontiersin.org
Though viruses have their own genomes, many depend on the nuclear environment of their
hosts for replication and survival. A substantial body of work has therefore been devoted to …

Epigenetic reprogramming of Kaposi's sarcoma-associated herpesvirus during hypoxic reactivation

RK Singh, D Bose, ES Robertson - Cancers, 2022 - mdpi.com
Simple Summary Epigenetic reprogramming of the KSHV genome plays a central role in
lytic replication of Kaposi's sarcoma-associated herpesvirus (KSHV). Hypoxia, a common …

[HTML][HTML] Lying low-chromatin insulation in persistent DNA virus infection

CS Varghese, JL Parish, J Ferguson - Current Opinion in Virology, 2022 - Elsevier
Persistent virus infections are achieved when the intricate balance of virus replication, host-
cell division and successful immune evasion is met. The genomes of persistent DNA viruses …

Epigenetic and epitranscriptomic regulation during oncogenic γ-herpesvirus infection

RK Singh, R Vangala, AS Torne, D Bose… - Frontiers in …, 2025 - frontiersin.org
Oncogenic gamma herpesviruses, including Epstein–Barr Virus (EBV) and Kaposi's
Sarcoma-associated Herpesvirus (KSHV), are opportunistic cancer-causing viruses and …