An insight into the recent development of the clinical candidates for the treatment of malaria and their target proteins

H Madhav, N Hoda - European Journal of Medicinal Chemistry, 2021 - Elsevier
Malaria is an endemic disease, prevalent in tropical and subtropical regions which cost half
of million deaths annually. The eradication of malaria is one of the global health priority …

A promising class of antiprotozoal agents, design and synthesis of novel Pyrimidine–Cinnamoyl hybrids

F Kayamba, R Karpoormath, VA Obakachi… - European Journal of …, 2025 - Elsevier
Malaria, caused by parasitic protozoans of the Plasmodium genus, continues to be one of
the greatest global health crises, especially in Africa. The emergence of antimalarial drug …

[PDF][PDF] Induction of Amodiaquine Metabolism by Rifampicin Following Concurrent Administration in Healthy Volunteers

AA Ademisoye, JO Soyinka, SO Olawoye… - Journal of Exploratory …, 2018 - researchgate.net
Background and objective: Malaria and tuberculosis remain endemic in tropical regions and
most often coexist, increasing the burden of malaria mortality due to unintended interactions …

[PDF][PDF] Antimalarial activity of ethanol extract of Mucuna pruriens leaves on Nk65 Chloroquine sensitive strain of plasmodium berghei

OE Ezim, OV Alagbe, FM Idih - J Complement Altern Med Res, 2021 - academia.edu
Mucuna pruriens leaves are used in some part of Nigeria for the treatment of malaria and
anemia. With an estimated 3.3 billion people in 97 countries and territories at risk of being …

[PDF][PDF] Antiplasmodial Effect of Ethanol Extract of Morinda lucida and Mucuna pruriens Leaves on NK65 Chloroquine Resistant Strain of Plasmodium berghei in Mice …

FM Idih, CC Ighorodje-Monago, OE Ezim - Clin Exp Pharmacol, 2017 - academia.edu
The study evaluated the Antiplasmodial effect of ethanol extract of Morinda lucida (ML) and
Mucuna pruriens (MP) leaves administered in combination on NK65 chloroquine resistant …

Anti-plasmodial activity of rifampicin/dihydro-artemisinin/piperaquine combination on Plasmodium berghei infected mice

GU Owunari, DJO Victor - GSC Biological and Pharmaceutical …, 2022 - gsconlinepress.com
Introduction: The huge cost of de-novo drug development and the problem of multidrug
resistance by plasmodium parasites has made research on drugs with potential for …

Antimalarial-Antibiotic Combination for Malaria: Evaluation of the Potential Toxicity and Safety of the Combinations of Amodiaquine-Ciprofloxacin and Amodiaquine …

HA Olumoh-Abdul, O Akinola… - Archives of Basic and …, 2022 - ojshostng.com
The combinations of antibiotics with standard anti-malarial drugs have been documented as
potentially valuable chemotherapeutic options for the management of drug-resistant malaria …

Identifizierung neuer antiplasmodialer Wirkstoffe und Validierung von PfGSK3 als potentiellen Medikamentenangriffspunkt gegen Malaria

A Alder - 2020 - ediss.sub.uni-hamburg.de
Mit über 228 Mio. Infektionen im Jahr 2018, von denen ca. 405 000 tödlich verliefen, ist
Malaria eine der bedeutendsten Infektionskrankheiten der Welt. Verursacht wird die …

The Impact of Rifampicin on Antimalarial Activity of Piperaquine and Piperaquine/Dihydroartemisinin Combination.

JJ Oloche, O Akinola, GO Gbotosho - Archives of Basic and Applied …, 2022 - ojshostng.com
Resistance to the available artemisinin-based combination therapy continues to threaten the
gains made through global efforts to control and eliminate malaria, one of the most severe …

Therapeutic Efficacy of Antibiotics in the Treatment of Chronic Diseases

V Khwaza, Z Mbese, BA Aderibigbe… - Antibiotic Materials in …, 2020 - Elsevier
Infectious and chronic diseases are the cause of high death rates globally. Antibiotics are
bioactive agents used for the treatment of bacterial infections. Chronic and infectious …