Host-mediated lung inflammation is present, and drives mortality, in the critical illness
caused by coronavirus disease 2019 (COVID-19). Host genetic variants associated with …

Critical COVID-19 is caused by immune-mediated inflammatory lung injury. Host genetic
variation influences the development of illness requiring critical care or hospitalization,–after …

Background The ISARIC prospective multinational observational study is the largest cohort
of hospitalized patients with COVID-19. We present relationships of age, sex, and nationality …

Delayed presentation of COVID-19 pneumonia increases the risk of mortality and need for
high-intensity healthcare. Conversely, early identification of COVID-19 pneumonia grants an …

The multidisciplinary nature of the work required for research in the COVID-19 pandemic
has created new challenges for health professionals in the battle against the virus. They …

Background For an emergent pandemic, such as COVID-19, the statistics of symptoms
based on hospital data may be biased or delayed due to the high proportion of …

Despite recent development of vaccines to prevent SARS-CoV-2 infection, treatment of
critically ill COVID-19 patients remains an important goal. In principle, genome-wide …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a pathogen with enteric
tropism. We compared the clinical, biochemical and radiological features of children …

Critical illness in COVID-19 is caused by inflammatory lung injury, mediated by the host
immune system. We and others have shown that host genetic variation influences the …

The clinical course and severity of COVID‐19 vary among patients. This study aimed to
investigate the potential correlation between the gene polymorphisms of the interferon …