Artificial enzymes, as alternatives to natural enzymes, have attracted enormous attention in
the fields of catalysis, biosensing, diagnostics, and therapeutics because of their high …

Advances in the site-specific chemical modification of proteins, also referred to as protein
bioconjugation, have proved instrumental in revolutionary approaches to designing new …

With the growing popularity of serine/threonine ligation (STL) and cysteine/penicillamine
ligation (CPL) in chemical protein synthesis, facile and general approaches for the …

Comprehensive Summary Expressed protein ligation (EPL) provides a powerful tool to
access large‐size proteins with precise structures. Existing methods for constructing the …

Comprehensive Summary Protein glycosylation is the most complex and diverse form of
post‐translational modification in human body. Meanwhile, glycosylation of peptides and …

A bioinspired semisynthesis of human‐interleukin‐6 bearing N‐glycan at Asn143
(143glycosyl‐IL‐6) was performed by intentional glycosylation effects and protein folding …

The incorporation of non-canonical amino acids (ncAAs) into the metal coordination
environments of proteins has endowed metalloproteins with enhanced properties and novel …

We report the molecular design of a novel multifunctional reagent and its application for light-
controlled selective protein labeling. This molecule integrates functions of protein–ligand …

Site-specific protein modification techniques have led to breakthroughs across diverse
fields, such as cell imaging, proteomics, biomaterials, and pharmaceutical protein and …

We describe a simple and robust oxidation strategy for preparing N-terminal thiazolidine-
containing peptide thioesters from peptide hydrazides. We find for the first time that l …