The lung is the main affected organ in severe coronavirus disease 2019 (COVID-19) caused
by the novel coronavirus SARS-CoV-2, and lung damage is the leading cause of death in …

Lung alveolar type-II (AT-II) cells produce pulmonary surfactant (PS), consisting of proteins
and lipids. The lipids in PS are primarily responsible for reducing the air-fluid surface tension …

Background Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) infection-
induced inflammatory responses are largely responsible for the death of novel coronavirus …

COVID-19 is linked to endotheliopathy and coagulopathy, which can result in multi-organ
failure. The mechanisms causing endothelial damage due to severe acute respiratory …

Given the highly variable clinical phenotype of Coronavirus disease 2019 (COVID-19), a
deeper analysis of the host genetic contribution to severe COVID-19 is important to improve …

Background The recent emergence of COVID-19, rapid worldwide spread, and incomplete
knowledge of molecular mechanisms underlying SARS-CoV-2 infection have limited …

The global spread of SARS-CoV-2 led to major economic and health challenges worldwide.
Revealing host genes essential for infection by multiple variants of SARS-CoV-2 can provide …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of the ongoing
coronavirus disease 2019 (COVID-19) pandemic. The continued spread of SARS-CoV-2 …

Early growth response 1 (EGR1) is a multifunctional mammalian transcription factor capable
of both enhancing and/or inhibiting gene expression. EGR1 can be activated by a wide array …

In this review, we discuss the role of pulmonary surfactant in the host defense against
respiratory pathogens, including novel coronavirus SARS-CoV-2. In the lower respiratory …