Structural biology of SARS-CoV-2: open the door for novel therapies

W Yan, Y Zheng, X Zeng, B He, W Cheng - Signal Transduction and …, 2022 - nature.com
Abstract Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) is the causative
agent of the pandemic disease COVID-19, which is so far without efficacious treatment. The …

[HTML][HTML] Natural therapeutics and nutraceuticals for lung diseases: traditional significance, phytochemistry, and pharmacology

MM Rahman, S Bibi, MS Rahaman, F Rahman… - Biomedicine & …, 2022 - Elsevier
Background Lung diseases including chronic obstructive pulmonary disease (COPD),
infections like influenza, acute respiratory distress syndrome (ARDS), asthma and …

COVID-19 and SARS-CoV-2. Modeling the present, looking at the future

E Estrada - Physics reports, 2020 - Elsevier
Abstract Since December 2019 the Severe Acute Respiratory Syndrome Coronavirus 2
(SARS-CoV-2) has produced an outbreak of pulmonary disease which has soon become a …

Targeting COVID-19 (SARS-CoV-2) main protease through active phytochemicals of ayurvedic medicinal plants – Withania somnifera (Ashwagandha), Tinospora cordifolia …

P Shree, P Mishra, C Selvaraj, SK Singh… - Journal of …, 2022 - Taylor & Francis
Abstract COVID-19 (Coronavirus disease 2019) is a transmissible disease initiated and
propagated through a new virus strain SARS-CoV-2 (Severe Acute Respiratory Syndrome …

A review on drug repurposing applicable to COVID-19

S Dotolo, A Marabotti, A Facchiano… - Briefings in …, 2021 - academic.oup.com
Drug repurposing involves the identification of new applications for existing drugs at a lower
cost and in a shorter time. There are different computational drug-repurposing strategies and …

Potential bioactive glycosylated flavonoids as SARS-CoV-2 main protease inhibitors: A molecular docking and simulation studies

SA Cherrak, H Merzouk, N Mokhtari-Soulimane - Plos one, 2020 - journals.plos.org
A novel coronavirus responsible of acute respiratory infection closely related to SARS-CoV
has recently emerged. So far there is no consensus for drug treatment to stop the spread of …

Drug design and repurposing with DockThor-VS web server focusing on SARS-CoV-2 therapeutic targets and their non-synonym variants

IA Guedes, LSC Costa, KB Dos Santos, ALM Karl… - Scientific Reports, 2021 - nature.com
The COVID-19 caused by the SARS-CoV-2 virus was declared a pandemic disease in
March 2020 by the World Health Organization (WHO). Structure-Based Drug Design …

Neutralizing aptamers block S/RBD‐ACE2 interactions and prevent host cell infection

X Liu, Y Wang, J Wu, J Qi, Z Zeng… - Angewandte Chemie …, 2021 - Wiley Online Library
The receptor‐binding domain (RBD) of the severe acute respiratory syndrome coronavirus 2
spike (S) protein plays a central role in mediating the first step of virus infection to cause …

Ivermectin as an adjunct treatment for hospitalized adult COVID-19 patients: a randomized multi-center clinical trial

MS Niaee, P Namdar, A Allami, L Zolghadr… - Asian Pacific Journal …, 2021 - journals.lww.com
Objective: To evaluate different doses of ivermectin in adult patients with mild COVID-19 and
to evaluate the effect of ivermectin on mortality and clinical consequences. Methods: A …

COVID‐19 drug repurposing: a review of computational screening methods, clinical trials, and protein interaction assays

X Wang, Y Guan - Medicinal research reviews, 2021 - Wiley Online Library
The situation of coronavirus disease 2019 (COVID‐19) pandemic is rapidly evolving, and
medical researchers around the globe are dedicated to finding cures for the disease. Drug …