Glucocorticoids are steroid hormones with key roles in the regulation of many physiological
systems including energy homeostasis and immunity. However, chronic glucocorticoid …

Chronic kidney disease (CKD) describes the long-term condition of impaired kidney function
from any cause. CKD is common and associated with a wide array of complications …

Background Breast cancer (BC) has the highest cancer incidence and mortality in women
worldwide. Observational epidemiological studies suggest a positive association between …

Corticosteroid-binding globulin (CBG) is a 50–60 kDa circulating glycoprotein with high
affinity for cortisol. CBG is adapted for sepsis; its cortisol binding is reduced reversibly by …

Context Prolonged exposure to pathological cortisol, as in Cushing's syndrome causes
various age-related disorders, including sarcopenia. However, it is unclear whether mild …

Technological advancement, data democratisation, and decreasing costs have led to a
revolution in molecular biology in which the entire set of DNA, RNA, proteins, and various …

Abstract 'You can't roll the clock back and reverse the effects of experiences' Bruce McEwen
used to say when explaining how allostasis labels the adaptive process. Here we will for …

Background Idiopathic interstitial pneumonias (IIPs), such as idiopathic pulmonary fibrosis
and interstitial pneumonia with autoimmune features, present diagnostic and therapeutic …

Background: Metabolic syndrome (MetS) and chronic kidney disease (CKD) are commonly
associated with cardiovascular disease (CVD) and in these patients Mg concentration is …

Background Observational studies and randomized controlled trials have found evidence
that higher maternal circulating cortisol levels in pregnancy are associated with lower …