Oligodendrocytes generate multiple layers of myelin membrane around axons of the central
nervous system to enable fast and efficient nerve conduction. Until recently, saltatory nerve …

Sphingolipids are highly enriched in the nervous system where they are pivotal constituents
of the plasma membranes and are important for proper brain development and functions …

Oligodendrocytes, the myelin-forming cells of the central nervous system (CNS), and
astrocytes constitute macroglia. This review deals with the recent progress related to the …

▪ Abstract Researchers have long predicted that complex carbohydrates on cell surfaces
would play important roles in developmental processes because of the observation that …

Rapid conduction of nerve impulses requires coating of axons by myelin sheaths, which are
lipid-rich and multilamellar membrane stacks. The lipid composition of myelin varies …

The evolution of complex nervous systems in vertebrates has been accompanied by, and
probably dependent on, the acquisition of the myelin sheath. Although there has been …

Efficient and rapid propagation of action potentials in myelinated axons depends on the
molecular specialization of the nodes of Ranvier. The nodal region is organized into several …

▪ Abstract The four essential building blocks of cells are proteins, nucleic acids, lipids, and
glycans. Also referred to as carbohydrates, glycans are composed of saccharides that are …

Interleukin-1β (IL-1β) is a proinflammatory cytokine associated with the pathophysiology of
demyelinating disorders such as multiple sclerosis and viral infections of the CNS. However …

Myelinated fibers are organized into distinct domains that are necessary for saltatory
conduction. These domains include the nodes of Ranvier and the flanking paranodal …