Structure and therapeutic uses of butyrylcholinesterase: application in detoxification, Alzheimer's disease, and fat metabolism

S Xing, Q Li, B Xiong, Y Chen, F Feng… - Medicinal Research …, 2021 - Wiley Online Library
Structural information of butyrylcholinesterase (BChE) and its variants associated with
several diseases are discussed here. Pure human BChE has been proved safe and effective …

New Insights into Butyrylcholinesterase: Pharmaceutical Applications, Selective Inhibitors and Multitarget-Directed Ligands

T Sun, T Zhen, CH Harakandi, L Wang, H Guo… - European Journal of …, 2024 - Elsevier
Butyrylcholinesterase (BChE), also known as pseudocholinesterase and serum
cholinesterase, is an isoenzyme of acetylcholinesterase (AChE). It mediates the degradation …

Oral administration of encapsulated catechin in chitosan‐alginate nanoparticles improves cognitive function and neurodegeneration in an aluminum chloride‐induced …

E Mohammadbaghban, A Taravati… - Physiological …, 2024 - Wiley Online Library
The present study aimed to investigate the effect of catechin‐loaded Chitosan‐Alginate
nanoparticles (NPs) on cognitive function in an aluminum chloride (AlCl3)‐induced rat …

Advances in design strategies and imaging applications of specific butyrylcholinesterase probes

T Sun, Z Dong, PM Malugulu, T Zhen, L Wang… - Chinese Chemical …, 2024 - Elsevier
Butyrylcholinesterase (BChE) is a pivotal enzyme that degrades the neurotransmitter
acetylcholine, which is related to learning and memory, into choline and acetic acid. BChE …

New benzamide derivatives and their nicotinamide/cinnamamide analogs as cholinesterase inhibitors

M Koca, S Bilginer - Molecular Diversity, 2022 - Springer
In this study, a total of 18 new benzamide/nicotinamide/cinnamamide derivative compounds
were designed and synthesized for the first time (except B1 and B5) by conventional and …

[HTML][HTML] The selective butyrylcholinesterase inhibitor UW‐MD‐95 shows symptomatic and neuroprotective effects in a pharmacological mouse model of Alzheimer's …

A Carles, M Hoffmann, M Scheiner… - CNS Neuroscience & …, 2024 - ncbi.nlm.nih.gov
Aims Alzheimer's disease (AD) is a devastating dementia characterized by extracellular
amyloid‐β (Aβ) protein aggregates and intracellular tau protein deposition. Clinically …

Design, synthesis, and in vitro evaluation of novel 1, 3, 4-oxadiazolecarbamothioate derivatives of Rivastigmine as selective inhibitors of BuChE

A Fallah, F Mohanazadeh, M Safavi - Medicinal Chemistry Research, 2020 - Springer
Rivastigmine has been prescribed for the therapy of Alzheimer's disease (AD) symptoms.
This drug is classified in the carbamate derivative group that has dual activity against …

A Review on the Anticancer Activity of Carbazole-based Tricyclic Compounds

H Zhang, W Zhang, M Zhu… - Current Medicinal …, 2024 - benthamdirect.com
Cancers are a huge threat to human life and health. Every year, many people suffer and die
from various cancers, and numerous resources have been used to combat cancer. Due to …

丁酰胆碱酯酶在阿尔茨海默病中的作用及其抑制剂设计策略

邢帅帅, 孙昊鹏 - 药学进展, 2023 - pps.cpu.edu.cn
近年来, 随着预期寿命的增长, 全球人口老龄化逐渐加剧, 多种老年疾病为社会保障体系以及个人
家庭生活带来诸多压力, 其中最为常见的一种便是阿尔茨海默病. 目前临床试验中用于治疗阿尔 …

pH-responsive Chitosan/alginate as a Suitable Nanocarrier for Efficient Oral Delivery of Catechin in Aluminum Chloride-induced Brain Injury

E Mohammadbaghban, A Taravati… - 2022 - researchsquare.com
Although, numerous clinical studies have shown the efficacy of catechin as a main bioactive
compound in green tea, which has demonstrated a capacity in prevention and treatment of a …