Small molecule metabolites: discovery of biomarkers and therapeutic targets

S Qiu, Y Cai, H Yao, C Lin, Y Xie, S Tang… - Signal Transduction and …, 2023 - nature.com
Metabolic abnormalities lead to the dysfunction of metabolic pathways and metabolite
accumulation or deficiency which is well-recognized hallmarks of diseases. Metabolite …

Gut microbiota in COVID-19: key microbial changes, potential mechanisms and clinical applications

F Zhang, RI Lau, Q Liu, Q Su, FKL Chan… - Nature Reviews …, 2023 - nature.com
The gastrointestinal tract is involved in coronavirus disease 2019 (COVID-19) caused by
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). The gut microbiota has …

Gut microbiota and microbial metabolism in early risk of cardiometabolic disease

CL Gabriel, JF Ferguson - Circulation Research, 2023 - Am Heart Assoc
Cardiometabolic disease comprises cardiovascular and metabolic dysfunction and
underlies the leading causes of morbidity and mortality, both within the United States and …

Association between Gut Microbiota and SARS-CoV-2 Infection and Vaccine Immunogenicity

HY Ng, WK Leung, KS Cheung - Microorganisms, 2023 - mdpi.com
Gut microbiota is increasingly recognized to play a pivotal role in various human
physiological functions and diseases. Amidst the COVID-19 pandemic, research has …

Baseline gut microbiome signatures correlate with immunogenicity of SARS-CoV-2 mRNA vaccines

L Daddi, Y Dorsett, T Geng, S Bokoliya, H Yuan… - International Journal of …, 2023 - mdpi.com
The powerful immune responses elicited by the mRNA vaccines targeting the SARS-CoV-2
Spike protein contribute to their high efficacy. Yet, their efficacy can vary greatly between …

Alterations in the gut microbiome and its metabolites are associated with the immune response to mucosal immunization with Lactiplantibacillus plantarum-displaying …

IC Hwang, R Vasquez, JH Song… - Frontiers in Cellular …, 2023 - frontiersin.org
Lactic acid bacteria (LAB) expressing foreign antigens have great potential as mucosal
vaccines. Our previous study reported that recombinant Lactiplantibacillus plantarum SK156 …

Unveiling the potential pleiotropic effects of metformin in treating COVID-19: A comprehensive review

P Petakh, I Kamyshna, A Kamyshnyi - Frontiers in Molecular …, 2023 - frontiersin.org
This review article explores the potential of metformin, a medication commonly used for type
2 diabetes, as an antiviral and anti-inflammatory agent in the context of coronavirus disease …

Baseline gut microbiota and metabolome predict durable immunogenicity to SARS-CoV-2 vaccines

Y Peng, L Zhang, CKP Mok, JYL Ching… - Signal transduction and …, 2023 - nature.com
The role of gut microbiota in modulating the durability of COVID-19 vaccine immunity is yet
to be characterised. In this cohort study, we collected blood and stool samples of 121 …

Therapeutic effects of epigallocatechin-3-gallate for inflammatory bowel disease: A preclinical meta-analysis

F Wei, D Li, X Chen, Y Li, Y Zeng, Y Cai, Y Zeng… - Phytomedicine, 2024 - Elsevier
Abstract Background Epigallocatechin-3-gallate (EGCG), the primary active compound in
green tea, is recognized for its significant anti-inflammatory properties and potential …

Systems biology of B cells in COVID-19

MC Woodruff, CE Faliti, I Sanz - Seminars in Immunology, 2024 - Elsevier
The integration of multi-'omic datasets into complex systems-wide assessments has become
a mainstay in immunologic investigation. This focus on high-dimensional data collection and …