Hypericin and its anticancer effects: From mechanism of action to potential therapeutic application

N Choudhary, TE Collignon, D Tewari, A Bishayee - Phytomedicine, 2022 - Elsevier
Background Emerging studies indicate that hypericin has diverse pharmacological actions
and exhibits potential for treatment of various types of cancer. Purpose The current review …

Hypericin as a promising natural bioactive naphthodianthrone: A review of its pharmacology, pharmacokinetics, toxicity, and safety

Z Peng, J Lu, K Liu, L Xie, Y Wang, C Cai… - Phytotherapy …, 2023 - Wiley Online Library
Hypericin can be derived from St. John's wort, which is widely spread around the world. As a
natural product, it has been put into clinical practice such as wound healing and depression …

Identification of Major Constituents of Hypericum perforatum L. Extracts in Syria by Development of a Rapid, Simple, and Reproducible HPLC-ESI-Q-TOF MS Analysis …

A Alahmad, I Alghoraibi, R Zein, S Kraft, G Dräger… - ACS …, 2022 - ACS Publications
Hypericum perforatum Linn (St. John's wort) is a popular and widespread medicine in Syria,
which is used for a wide range of conditions, including gastrointestinal diseases, heart …

Dermal drug delivery of phytochemicals with phenolic structure via lipid-based nanotechnologies

V Gugleva, N Ivanova, Y Sotirova, V Andonova - Pharmaceuticals, 2021 - mdpi.com
Phenolic compounds are a large, heterogeneous group of secondary metabolites found in
various plants and herbal substances. From the perspective of dermatology, the most …

Advanced application of nanotechnology in active constituents of Traditional Chinese Medicines

C Qiu, JZ Zhang, B Wu, CC Xu, HH Pang… - Journal of …, 2023 - Springer
Abstract Traditional Chinese Medicines (TCMs) have been used for centuries for the
treatment and management of various diseases. However, their effective delivery to targeted …

The flower of Hypericum perforatum L.: A traditional source of bioactives for new food and pharmaceutical applications

S Kapoor, R Chandel, R Kaur, S Kumar… - Biochemical Systematics …, 2023 - Elsevier
In recent years, globalization has stimulated the growth of the food processing industry to
meet the daily demand for a variety of food products. In this context, there has been a …

Hypericin-based photodynamic therapy displays higher selectivity and phototoxicity towards melanoma and squamous cell cancer compared to normal keratinocytes …

M Woźniak, M Nowak-Perlak - International Journal of Molecular Sciences, 2023 - mdpi.com
The aim of this study was to explore the potential of hypericin, a naturally occurring
photosensi-tizer, for photodynamic therapy (PDT) in skin cancer, investigating its phototoxic …

[HTML][HTML] A review of the efficacy of nanomaterial-based natural photosensitizers to overcome multidrug resistance in cancer

J Rajaram, LK Mende, Y Kuthati - Pharmaceutics, 2024 - pmc.ncbi.nlm.nih.gov
Natural photosensitizers (PS) are compounds derived from nature, with photodynamic
properties. Natural PSs have a similar action to that of commercial PSs, where cancer cell …

Unravelling Phytochemical and Bioactive Potential of Three Hypericum Species from Romanian Spontaneous Flora: H. alpigenum, H. perforatum and H. rochelii

M Babotă, O Frumuzachi, A Mocan, M Tămaș, MI Dias… - Plants, 2022 - mdpi.com
Hypericum perforatum L., also known as St. John's Wort, is recognized worldwide as a
valuable medicinal herb; however, other Hypericum species were intensively studied for …

High purity separation of hypericin from Hypericum perforatum L. extract with macroporous resin column coupling preparative liquid chromatography

J Zhang, C Feng, P Ge, Q Wang, Y Liu, H Xu… - Process Biochemistry, 2021 - Elsevier
Hypericin has shown promising potential for the prevention and treatment of cancer. Here
we report facile strategy for the separation and purification of natural products from the …