The introduction of AlphaFold 21 has spurred a revolution in modelling the structure of
proteins and their interactions, enabling a huge range of applications in protein modelling …

Aptamers are single-stranded DNA or RNA oligonucleotides generated by SELEX that
exhibit binding affinity and specificity against a wide variety of target molecules. Compared …

We present a comprehensive toolkit for Förster resonance energy transfer (FRET)-restrained
modeling of biomolecules and their complexes for quantitative applications in structural …

Recent methodological and instrumental advances in solution-state nuclear magnetic
resonance have opened up the way to investigating challenging problems in structural …

Structural, regulatory and enzymatic proteins interact with DNA to maintain a healthy and
functional genome. Yet, our structural understanding of how proteins interact with DNA is …

Nucleic acid–ligand interactions play an important role in numerous cellular processes such
as gene function expression and regulation. Therefore, nucleic acids such as RNAs have …

Proteins and nucleic acids are essential biological macromolecules for cell life. Indeed,
interactions between proteins and DNA regulate many biological processes such as protein …

Nucleic acid–ligand complexes underlie numerous cellular processes, such as gene
function expression and regulation, in which their three-dimensional structures are important …

Modeling biomolecular assemblies is an important field in computational structural biology.
The inherent complexity of their energy landscape and the computational cost associated …

Incorporating the dynamic nature of biomolecules in the modeling of their complexes is a
challenge, especially when the extent and direction of the conformational changes taking …