Poisoning is a frequent cause of referral to medical emergencies and a major health
problem around the world, especially in developing countries. We aimed to review the …

Methods The Canadian Research Initiative in Substance Misuse (CRISM), a Canadian
Institutes of Health Research (CIHR)–funded research network composed of four regional …

Maintenance therapy with methadone or buprenorphine‐based regimens reduces opioid
dependence and associated harms. The perception that methadone is more effective than …

Background Specialist drug treatment is critical to overdose prevention; methadone
maintenance is effective, but we lack evidence for other modalities. We evaluate the impact …

Context Limitations of existing pharmacological treatments for opioid dependence include
low adherence, medication diversion, and emergence of withdrawal symptoms. Objective To …

Objective: Both methadone and buprenorphine are effective therapy for heroin dependence.
Efficacy is best documented for methadone maintenance therapy, but safety concerns limit …

Aim To compare retention in treatment and mortality among people entering methadone and
buprenorphine treatment for opioid dependence. Data sources The Pharmaceutical Drugs of …

Aims To evaluate the safety and efficacy of buprenorphine implants (BI) versus placebo
implants (PI) for the treatment of opioid dependence. A secondary aim compared BI to open …

Objective To assess the efficacy of slow release oral morphine (SROM) as a treatment for
opioid use disorder (OUD). Design Systematic review and meta-analysis of randomised …

Abstract Since 2000 there have been 915,515 people who have died from a drug overdose
in the United States (US). This number continues to increase and in 2021 drug overdose …