Candida Infections, Causes, Targets, and Resistance Mechanisms: Traditional and Alternative Antifungal Agents

C Spampinato, D Leonardi - BioMed research international, 2013 - Wiley Online Library
The genus Candida includes about 200 different species, but only a few species are human
opportunistic pathogens and cause infections when the host becomes debilitated or …

Factors influencing the magnitude and clinical significance of drug interactions between azole antifungals and select immunosuppressants

AH Saad, DD DePestel… - … : The Journal of Human …, 2006 - Wiley Online Library
The magnitude of drug interactions between azole antifungals and immunosuppressants is
drug and patient specific and depends on the potency of the azole inhibitor involved, the …

Synthesis and antifungal activity of (Z)-5-arylidenerhodanines

M Sortino, P Delgado, S Juárez, J Quiroga… - Bioorganic & Medicinal …, 2007 - Elsevier
An efficient microwave-assisted synthesis of new (Z)-5-arylidenerhodanines under solvent-
free conditions is described and their in vitro antifungal activity was evaluated following the …

Perspectives for the management of febrile neutropenic patients with cancer in the 21st century

NV Sipsas, GP Bodey… - … International Journal of …, 2005 - Wiley Online Library
Over the past several decades, there has been substantial progress in the management of
patients with febrile neutropenia. However, the ever‐changing patterns of infection, ecology …

Evidence for the Mechanism of Action of the Antifungal Phytolaccoside B Isolated from Phytolacca tetramera Hauman

A Escalante, M Gattuso, P Pérez… - Journal of Natural …, 2008 - ACS Publications
Phytolaccoside B (1), an antifungal monodesmoside triterpenoid glycoside isolated from
berries of Phytolacca tetramera Hauman (Phytolaccaceae), alters the morphology of yeasts …

Combinations of antifungal agents in therapy–what value are they?

M Cuenca-Estrella - Journal of antimicrobial chemotherapy, 2004 - academic.oup.com
Concurrent or sequential antifungal treatment for invasive mycoses has been typically
considered as an option to improve results of monotherapy. However, data on the efficacy of …

A new group of antifungal and antibacterial lipopeptides derived from non-membrane active peptides conjugated to palmitic acid

D Avrahami, Y Shai - Journal of Biological Chemistry, 2004 - ASBMB
We report on the synthesis, biological function, and a plausible mode of action of a new
group of lipopeptides with potent antifungal and antibacterial activities. These lipopeptides …

Posaconazole

GM Keating - Drugs, 2005 - Springer
Abstract▴ Posaconazole is a triazole antifungal agent, administered as an oral suspension,
with an extended spectrum of in vitro activity.▴ Posaconazole 800 mg/day demonstrated …

Antifungal Activity and Mechanism of Action of the Co(III) Coordination Complexes With Diamine Chelate Ligands Against Reference and Clinical Strains of Candida …

K Turecka, A Chylewska, A Kawiak… - Frontiers in …, 2018 - frontiersin.org
Although many antifungal agents are available in clinical treatment, increasing resistance of
fungi, especially Candida species, to the available drugs requires the development of new …

Targeting Adhesion in Fungal Pathogen Candida Albicans

H Martin, K Kavanagh… - Future Medicinal …, 2021 - Taylor & Francis
Fungal infections with increasing resistance to conventional therapies are a growing
concern. Candida albicans is a major opportunistic yeast responsible for mucosal and …