NF-κB pathway consists of canonical and non-canonical pathways. The canonical NF-κB is
activated by various stimuli, transducing a quick but transient transcriptional activity, to …

Plasmacytoid dendritic cells (pDCs) are a unique DC subset that specializes in the
production of type I interferons (IFNs). pDCs promote antiviral immune responses and have …

Toll-like receptors (TLRs) are germline-encoded pattern recognition receptors (PRRs) that
play a central role in host cell recognition and responses to microbial pathogens. TLR …

To gain further insight into the genetic architecture of psoriasis, we conducted a meta-
analysis of 3 genome-wide association studies (GWAS) and 2 independent data sets …

A major challenge in inflammatory bowel disease (IBD) is the integration of diverse IBD data
sets to construct predictive models of IBD. We present a predictive model of the immune …

Endosomal Toll-like receptors (TLRs) 7 and 9 recognize viral pathogens and induce signals
leading to the activation of nuclear factor κB (NF-κB)–dependent proinflammatory cytokines …

Plasmacytoid dendritic cells (pDCs) comprise a subset of dendritic cells characterized by
their ability to produce large amount of type I interferon (IFN-I/α). Originally recognized for …

Background Combined immunodeficiencies are marked by inborn errors of T-cell immunity
in which the T cells that are present are quantitatively or functionally deficient. Impaired …

The innate immune system recognizes microbial components through pattern‐recognition
receptors (PRRs), including membrane‐bound Toll‐like receptors and cytosolic receptors …

Summary Toll-like receptor 7 (TLR7) and TLR9 sense viral nucleic acids and induce
production of type I interferon (IFN) by plasmacytoid dendritic cells (pDCs) to protect the host …