Astrocyte function from information processing to cognition and cognitive impairment

M Santello, N Toni, A Volterra - Nature neuroscience, 2019 - nature.com
Astrocytes serve important roles that affect recruitment and function of neurons at the local
and network levels. Here we review the contributions of astrocyte signaling to synaptic …

Important shapeshifter: mechanisms allowing astrocytes to respond to the changing nervous system during development, injury and disease

J Schiweck, BJ Eickholt, K Murk - Frontiers in cellular neuroscience, 2018 - frontiersin.org
Astrocytes are the most prevalent glial cells in the brain. Historically considered as “merely
supporting” neurons, recent research has shown that astrocytes actively participate in a …

Astrocytes contribute to remote memory formation by modulating hippocampal–cortical communication during learning

A Kol, A Adamsky, M Groysman, T Kreisel… - Nature …, 2020 - nature.com
Remote memories depend on coordinated activity in the hippocampus and frontal cortices,
but the timeline of these interactions is debated. Astrocytes sense and modify neuronal …

Impaired calcium signaling in astrocytes modulates autism spectrum disorder-like behaviors in mice

Q Wang, Y Kong, DY Wu, JH Liu, W Jie, QL You… - Nature …, 2021 - nature.com
Autism spectrum disorder (ASD) is a common neurodevelopmental disorder. The
mechanisms underlying ASD are unclear. Astrocyte alterations are noted in ASD patients …

NG2 glia-derived GABA release tunes inhibitory synapses and contributes to stress-induced anxiety

X Zhang, Y Liu, X Hong, X Li, CK Meshul… - Nature …, 2021 - nature.com
NG2 glia, also known as oligodendrocyte precursor cells (OPCs), play an important role in
proliferation and give rise to myelinating oligodendrocytes during early brain development …

Gi/o protein‐coupled receptors inhibit neurons but activate astrocytes and stimulate gliotransmission

CA Durkee, A Covelo, J Lines, P Kofuji, J Aguilar… - Glia, 2019 - Wiley Online Library
G protein‐coupled receptors (GPCRs) play key roles in intercellular signaling in the brain.
Their effects on cellular function have been largely studied in neurons, but their functional …

The ATP level in the medial prefrontal cortex regulates depressive-like behavior via the medial prefrontal cortex-lateral habenula pathway

S Lin, L Huang, Z Luo, X Li, S Jin, Z Du, D Wu… - Biological …, 2022 - Elsevier
Background Depression is the most common mental illness. Mounting evidence suggests
that dysregulation of extracellular ATP (adenosine triphosphate) is involved in the …

Astrocyte regulation of neural circuit activity and network states

JF Oliveira, A Araque - Glia, 2022 - Wiley Online Library
Astrocytes are known to influence neuronal activity through different mechanisms, including
the homeostatic control of extracellular levels of ions and neurotransmitters and the …

Activated astrocytes attenuate neocortical seizures in rodent models through driving Na+-K+-ATPase

J Zhao, J Sun, Y Zheng, Y Zheng, Y Shao, Y Li… - Nature …, 2022 - nature.com
Epileptic seizures are widely regarded to occur as a result of the excitation-inhibition
imbalance from a neuro-centric view. Although astrocyte-neuron interactions are …

Activation of astrocytes in hippocampus decreases fear memory through adenosine A1 receptors

Y Li, L Li, J Wu, Z Zhu, X Feng, L Qin, Y Zhu, L Sun… - Elife, 2020 - elifesciences.org
Astrocytes respond to and regulate neuronal activity, yet their role in mammalian behavior
remains incompletely understood. Especially unclear is whether, and if so how, astrocyte …