Nucleic acids modulate liquidity and dynamics of artificial membraneless organelles
J Liu, F Zhorabek, Y Chau - ACS Macro Letters, 2022 - ACS Publications
Liquid–liquid phase separation (LLPS) emerges as a fundamental underlying mechanism
for the biological organization, especially the formation of membraneless organelles (MLOs) …
for the biological organization, especially the formation of membraneless organelles (MLOs) …
RNA folding kinetics control riboswitch sensitivity in vivo
DZ Bushhouse, J Fu, JB Lucks - Nature Communications, 2025 - nature.com
Riboswitches are ligand-responsive gene-regulatory RNA elements that perform key roles in
maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) …
maintaining cellular homeostasis. Understanding how riboswitch sensitivity to ligand (EC50) …
Understanding the relative flexibility of RNA and DNA duplexes: stretching and twist-stretch coupling
L Bao, X Zhang, YZ Shi, YY Wu, ZJ Tan - Biophysical journal, 2017 - cell.com
The flexibility of double-stranded (ds) RNA and dsDNA is crucial for their biological
functions. Recent experiments have shown that the flexibility of dsRNA and dsDNA can be …
functions. Recent experiments have shown that the flexibility of dsRNA and dsDNA can be …
Refining the RNA force field with small-angle X-ray scattering of helix–junction–helix RNA
The growing recognition of the functional and therapeutic roles played by RNA and the
difficulties in gaining atomic-level insights by experiments are paving the way for all-atom …
difficulties in gaining atomic-level insights by experiments are paving the way for all-atom …
Structural flexibility of DNA-RNA hybrid duplex: stretching and twist-stretch coupling
Abstract DNA-RNA hybrid (DRH) duplexes play essential roles during the replication of DNA
and the reverse transcription of RNA viruses, and their flexibility is important for their …
and the reverse transcription of RNA viruses, and their flexibility is important for their …
Visualizing RNA structures by SAXS-driven MD simulations
W He, A Henning-Knechtel, S Kirmizialtin - Frontiers in Bioinformatics, 2022 - frontiersin.org
The biological role of biomolecules is intimately linked to their structural dynamics.
Experimental or computational techniques alone are often insufficient to determine accurate …
Experimental or computational techniques alone are often insufficient to determine accurate …
Additional principles that govern the release of pre-ribosomes from the nucleolus into the nucleoplasm in yeast
AJ LaPeruta, J Micic, JL Woolford Jr - Nucleic acids research, 2023 - academic.oup.com
During eukaryotic ribosome biogenesis, pre-ribosomes travel from the nucleolus, where
assembly is initiated, to the nucleoplasm and then are exported to the cytoplasm, where …
assembly is initiated, to the nucleoplasm and then are exported to the cytoplasm, where …
Visualizing disordered single-stranded RNA: connecting sequence, structure, and electrostatics
Disordered homopolymeric regions of single-stranded RNA, such as U or A tracts, are found
within functional RNAs where they play distinct roles in defining molecular structure and …
within functional RNAs where they play distinct roles in defining molecular structure and …
Pressure pushes tRNALys3 into excited conformational states
Conformational dynamics play essential roles in RNA function. However, detailed structural
characterization of excited states of RNA remains challenging. Here, we apply high …
characterization of excited states of RNA remains challenging. Here, we apply high …
Modeling structure, stability, and flexibility of double-stranded RNAs in salt solutions
Double-stranded (ds) RNAs play essential roles in many processes of cell metabolism. The
knowledge of three-dimensional (3D) structure, stability, and flexibility of dsRNAs in salt …
knowledge of three-dimensional (3D) structure, stability, and flexibility of dsRNAs in salt …