Polynucleotides encoding anti-CD20 antigen binding molecules with increased Fc receptor binding affinity and effector function

P Umana, P Brünker, CF Koller, T Suter… - US Patent …, 2016 - Google Patents
The present invention relates to nucleic acids encoding anti-CD20 antigen binding
molecules (ABMs). In particular embodiments, the present invention relates to nucleic acid …

Anti-CD3 antibodies, bispecific antigen-binding molecules that bind CD3 and CD20, and uses thereof

E Smith, NJ Papadopoulos - US Patent 9,657,102, 2017 - Google Patents
First worldwide family litigation filed litigation Critical https://patents. darts-ip. com/? family=
49304338&utm_source= google_patent&utm_medium= platform_link&utm_campaign …

Binding domain-immunoglobulin fusion proteins

JA Ledbetter, MS Hayden-Ledbetter - US Patent 8,106,161, 2012 - Google Patents
The invention relates to novel binding domain-immunoglo bulin fusion proteins that feature a
binding domain for a cognate structure Such as an antigen, a counterreceptor or the like, a …

Single chain multivalent binding proteins with effector function

PA Thompson, JA Ledbetter… - US Patent …, 2013 - Google Patents
Multivalent binding peptides, including bi-specific binding peptides, having immunoglobulin
effector function are provided, along with encoding nucleic acids, vectors and host cells as …

Anti-CD20 antibodies

DR Anderson, N Hanna, RA Newman, ME Reff… - US Patent …, 2008 - Google Patents
Related US Application Data (60) Continuation of application No. 08/475,813, filed on Jun.
7, 1995, now Pat. No. 6,682,734, which is a divi sion of application No. 08/149,099, filed on …

Treatment of autoimmune diseases

JG Curd, LA Kunkel, AJ Grillo-Lopez - US Patent 7,820,161, 2010 - Google Patents
5,776.456 A 7, 1998 Anderson et al. Methods are disclosed of treating rheumatoid arthritis in
a 5,786,456 A 7, 1998 Ledbetter et al. human comprising administering to the human more …

Immunoglobulin variants and uses thereof

CW Adams, AC Chan, CW Crowley… - US Patent …, 2010 - Google Patents
US7799900B2 - Immunoglobulin variants and uses thereof - Google Patents US7799900B2 -
Immunoglobulin variants and uses thereof - Google Patents Immunoglobulin variants and …

Highly Concentrated Pharmaceutical Formulations

M Adler, HC Mahler, OB Stauch - US Patent App. 12/879,486, 2011 - Google Patents
The present invention relates to a highly concentrated, stable pharmaceutical formulation of
a pharmaceutically active anti-CD20 antibody, such as eg Rituximab, Ocrelizumab, or …

Variant Fc regions

B Allan, W Jiang, Y Tang, JD Watkins - US Patent 7,740,847, 2010 - Google Patents
Related US Application Data (60) Provisional application No. 60598.855, filed on
Aug.(Continued) 4, 2004, provisional application No. 60/602,953, filed on Aug. 19, 2004 …

Binding domain-immunoglobulin fusion proteins

JA Ledbetter, MS Hayden-Ledbetter - US Patent 9,005,612, 2015 - Google Patents
The invention relates to novel binding domain immunoglo bulin fusion proteins that feature a
binding domain for a cognate structure Such as an antigen, a counterreceptor or the like, a …