• The specific situation of the patient. Unless otherwise provided for by national regulations,
off-label use of medication should be limited to situations where it is in the patient's interest …

The global prevalence of atrial fibrillation (AF) has increased substantially over the past
three decades and is currently approximately 60 million cases. Incident AF and its clinical …

Abstract Aim The “2023 ACC/AHA/ACCP/HRS Guideline for the Diagnosis and Management
of Patients With Atrial Fibrillation” provides recommendations to guide clinicians in the …

The Japanese Society of Hypertension (JSH) revised the Guidelines for the Management of
Hypertension 2014 (JSH 2014), and published the JSH 2019. In the development of the JSH …

High systolic blood pressure (SBP) is a major risk factor for ischemic heart disease (IHD), the
leading cause of death worldwide. Using data from published observational studies and …

Atrial fibrillation (AF), the most common sustained cardiac arrhythmia, is associated with
substantial morbidity, mortality, and healthcare use. Great strides have been made in stroke …

Aims The expression of GADD153 (growth arrest and DNA damage-inducible gene 153), an
apoptosis-regulated gene, increases during endoplasmic reticulum (ER) stress. How …

Background The most appropriate targets for systolic blood pressure to reduce
cardiovascular morbidity and mortality among persons without diabetes remain uncertain …

Objective—To review the literature systematically and perform meta-analyses to address
these questions: 1) Is there evidence that self-measured blood pressure (BP) without other …

Background Recent hypertension guidelines have reversed previous recommendations for
lower blood pressure targets in high-risk patients, such as those with cardiovascular …