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This article reviews the discovery of PCSK9, its structure–function characteristics, and its
presently known and proposed novel biological functions. The major critical function of …

Aims To update the evidence about the diabetogenic effect of statins. Methods We searched
for randomized-controlled trials reporting the effects of statin therapy on glycosylated …

Background Myocardial infarction mortality has declined since the 1970s, but contemporary
drivers of this trend remain unexplained. The aim of this study was to compare the …

Background Timely recognition and appropriate treatment of attention-deficit/hyperactivity
disorder (ADHD) are essential to enhance long-term outcomes of individuals with ADHD …

Mammalian cells and tissues have the capacity to generate hydrogen sulfide gas (H2S) via
catabolic routes involving cysteine metabolism. H2S acts on cell signaling cascades that are …

Statins are included in the category of high-frequency prescription drugs, and their use is on
an upward trend worldwide. In 2012, the FDA issued a warning about possible cognitive …

Statins are the most prescribed lipid-lowering agents worldwide. Their use is generally safe,
although muscular toxicity occurs in about 1 in 10.000 patients. In this study, we explored the …

The widespread clinical use of statins has contributed to significant reductions of
cardiovascular morbidity and mortality. Increasing preclinical and epidemiological …

Cardiovascular inequalities remain pervasive in the European countries. Disparities in
disease burden is apparent among population groups based on sex, ethnicity, economic …