Can β-lactam antibiotics be resurrected to combat MRSA?
TJ Foster - Trends in microbiology, 2019 - cell.com
The use of β-lactam antibiotics to treat infections caused by Staphylococcus aureus has
been severely compromised by the acquisition by horizontal gene transfer of a gene that …
been severely compromised by the acquisition by horizontal gene transfer of a gene that …
Focused review on dual inhibition of quorum sensing and efflux pumps: a potential way to combat multi drug resistant Staphylococcus aureus infections
B Kaur, J Gupta, S Sharma, D Sharma… - International Journal of …, 2021 - Elsevier
Staphylococcus aureus is a common cause of skin infections, food poisoning and severe life-
threatening infections. Methicillin-Resistant Staphylococcus aureus (MRSA) is known to …
threatening infections. Methicillin-Resistant Staphylococcus aureus (MRSA) is known to …
Purine nucleosides interfere with c-di-AMP levels and act as adjuvants to re-sensitize MRSA to β-lactam antibiotics
AC Nolan, MS Zeden, I Kviatkovski, C Campbell… - Mbio, 2023 - Am Soc Microbiol
The purine-derived signaling molecules c-di-AMP and (p) ppGpp control mecA/PBP2a-
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
mediated β-lactam resistance in methicillin-resistant Staphylococcus aureus (MRSA) raise …
Metabolic reprogramming and altered cell envelope characteristics in a pentose phosphate pathway mutant increases MRSA resistance to β-lactam antibiotics
Central metabolic pathways control virulence and antibiotic resistance, and constitute
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
potential targets for antibacterial drugs. In Staphylococcus aureus the role of the pentose …
Modulation of MRSA virulence gene expression by the wall teichoic acid enzyme TarO
Y Lu, F Chen, Q Zhao, Q Cao, R Chen, H Pan… - Nature …, 2023 - nature.com
Phenol-soluble modulins (PSMs) and Staphylococcal protein A (SpA) are key virulence
determinants for community-associated methicillin-resistant Staphylococcus aureus (CA …
determinants for community-associated methicillin-resistant Staphylococcus aureus (CA …
Future trends in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) infection: An in-depth review of newer antibiotics active against an enduring …
Methicillin-resistant Staphylococcus aureus (MRSA) continues to be a major public health
problem. Vancomycin and teicoplanin have been in clinical use for several decades but their …
problem. Vancomycin and teicoplanin have been in clinical use for several decades but their …
Targeting Virulence in Staphylococcus aureus by Chemical Inhibition of the Accessory Gene Regulator System In Vivo
Methicillin-resistant Staphylococcus aureus (MRSA) presents one of the most serious health
concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing …
concerns worldwide. The WHO labeled it as a “high-priority” pathogen in 2017, also citing …
Prevalence of methicillin-resistant Staphylococcus aureus in healthy Chinese population: A system review and meta-analysis
M Wu, X Tong, S Liu, D Wang, L Wang, H Fan - PLoS One, 2019 - journals.plos.org
Objective To comprehensively determine the prevalence of MRSA in healthy Chinese
population, the influencing factors of MRSA colonization and its antibiotic resistance …
population, the influencing factors of MRSA colonization and its antibiotic resistance …
Early Administration of Adjuvant β‐Lactam Therapy in Combination with Vancomycin among Patients with Methicillin‐Resistant Staphylococcus aureus Bloodstream …
AM Casapao, DM Jacobs, DR Bowers… - … : The Journal of …, 2017 - Wiley Online Library
Study Objective To determine whether early administration of adjuvant β‐lactam in
combination with vancomycin (COMBO) affects clinical outcomes compared to standard …
combination with vancomycin (COMBO) affects clinical outcomes compared to standard …
The combination of daptomycin and fosfomycin has synergistic, potent, and rapid bactericidal activity against methicillin-resistant Staphylococcus aureus in a rabbit …
C García-de-la-Mària, O Gasch… - Antimicrobial agents …, 2018 - Am Soc Microbiol
We investigated whether the addition of fosfomycin or cloxacillin to daptomycin provides
better outcomes in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) …
better outcomes in the treatment of methicillin-resistant Staphylococcus aureus (MRSA) …