Background Organ transplantation is predicted to increase as life expectancy and the
incidence of chronic diseases rises. Regenerative medicine-inspired technologies …

The increasing life expectancy of humans has led to a growing numbers of patients with
chronic diseases and end-stage organ failure. Transplantation is an effective approach for …

Interspecies chimera formation with human pluripotent stem cells (hPSCs) represents a
necessary alternative to evaluate hPSC pluripotency in vivo and might constitute a …

Interspecies blastocyst complementation enables organ-specific enrichment of xenogenic
pluripotent stem cell (PSC) derivatives. Here, we establish a versatile blastocyst …

Of all known cultured stem cell types, pluripotent stem cells (PSCs) sit atop the landscape of
developmental potency and are characterized by their ability to generate all cell types of an …

Parental histones, the carriers of posttranslational modifications, are deposited evenly onto
the replicating DNA of sister chromatids in a process dependent on the Mcm2 subunit of …

Heterologous organ transplantation is an effective way of replacing organ function but is
limited by severe organ shortage. Although generating human organs in other large …

In contrast to non-mammalian vertebrates, mammals and humans have limited innate
capacity for the self-regeneration of tissues and organs owing to differences in genetics …

Induced pluripotent stem cells (iPSCs) can self-renew indefinitely in culture and differentiate
into all specialized cell types including gametes. iPSCs do not exist naturally and are …

¿ Es posible alargar la vida humana de forma indefinida por medio de la tecnología
genética? Y, en caso de que lo fuera,¿ qué repercusiones tendría eso sobre la sociedad y …