Part I of this article discussed the potential functional importance of genetic mutations and
alleles of the human cytochrome P450 2D6 (CYP2D6) gene. The impact of CYP2D6 …

Pharmacogenetics is the study of how interindividual variations in the DNA sequence of
specific genes affect drug response. This article highlights current pharmacogenetic …

Individuals suffering from depressive disorders display a greater incidence of hypertension
compared with the general population, despite reports of the association between …

The occurrence of idiosyncratic adverse drug reactions during late clinical trials or after a
drug has been released can lead to a severe restriction in its use and even in its withdrawal …

The selective serotonin reuptake inhibitors (SSRIs) have become the most prescribed
antidepressants in many countries. Although the SSRIs share a common mechanism of …

1. INTRODUCTION Cytochrome P450s (CYPs) constitute a superfamily of hemecontaining
enzymes that catalyze the oxidative metabolism of structurally diverse molecules including …

Atomoxetine (Strattera®), a potent and selective inhibitor of the presynaptic norepinephrine
transporter, is used clinically for the treatment of attention-deficit hyperactivity disorder …

Metoprolol, a commonly prescribed β‐blocker, is primarily metabolized by cytochrome P450
2D6 (CYP2D6), an enzyme with substantial genetic heterogeneity. Several smaller studies …

In this article, epidemiological and clinical aspects related to the use of antiepileptic drugs
(AEDs) in the elderly are highlighted. Studies have shown that people with epilepsy …

Preclinical drug metabolism studies play a key role in the lead identification and optimization
process in drug discovery. Characterization of the metabolic pathways of new chemical …