Cancer stem cells (CSCs), a small subset of cells in tumors that are characterized by self-
renewal and continuous proliferation, lead to tumorigenesis, metastasis, and maintain tumor …

Diffuse midline glioma (DMG) is the leading cause of brain tumor-related deaths in children.
DMG typically presents with variable neurologic symptoms between ages 3 and 10 …

Simple Summary Pediatric high-grade glioma (pHGG) has a dismal prognosis in which the
younger the patient, the more restricted the treatments are, in regard to the incurred risks …

Simple Summary Diffuse midline gliomas (DMGs) remain one of the most devastating
childhood brain tumour types, for which there is currently no known cure. In this review we …

The life expectancy of patients with high-grade glioma (HGG) has not improved in decades.
One of the crucial tools to enable future improvement is advanced models that faithfully …

Abstract H3K27-altered Diffuse Midline Glioma (DMG) is a universally fatal paediatric
brainstem tumour. The prevalent driver mutation H3K27M creates a unique epigenetic …

High-grade glioma (HGG) is the most common cause of cancer death in children and the
most common primary central nervous system tumor in adults. While pediatric HGG was …

Background 3D collagen scaffold culture is a good tool to study glioma metastasis and
recurrence in vitro. Methods The effect of 3D collagen culture on the colony formation, the …

Therapeutic resistance remains a major obstacle to successful clinical management of
diffuse intrinsic pontine glioma (DIPG), a high-grade pediatric tumor of the brain stem. In …

Abstract Background H3 K27M mutated diffuse midline gliomas (DMGs) are extremely
aggressive and the leading cause of cancer‐related deaths in pediatric brain tumors with 5 …