Antimicrobial-resistant ESKAPE (E nterococcus faecium, S taphylococcus aureus, K
lebsiella pneumoniae, A cinetobacter baumannii, P seudomonas aeruginosa, and E …

Klebsiella pneumoniae is a common cause of antimicrobial-resistant opportunistic infections
in hospitalized patients. The species is naturally resistant to penicillins, and members of the …

A global medical crisis is unfolding as antibiotics lose effectiveness against a growing
number of bacterial pathogens. Horizontal gene transfer (HGT) contributes significantly to …

ABSTRACT A hypervirulent Klebsiella pneumoniae (hvKp) pathotype is undergoing global
dissemination. In contrast to the usual health care-associated epidemiology of classical K …

Illumina sequencing platforms have enabled widespread bacterial whole genome
sequencing. While Illumina data is appropriate for many analyses, its short read length limits …

Antibiotic-resistant infections are an urgent problem in clinical settings because they sharply
increase mortality risk in critically ill patients. The horizontal spread of antibiotic resistance …

The dramatic increase in the prevalence and clinical impact of infections caused by bacteria
producing carbapenemases is a global health concern. Carbapenemase production is …

Background Whole genome sequence (WGS)-based strain typing finds increasing use in the
epidemiologic analysis of bacterial pathogens in both public health as well as more …

Klebsiella pneumoniae is now recognized as an urgent threat to human health because of
the emergence of multidrug-resistant strains associated with hospital outbreaks and …

Metagenomic next-generation sequencing (mNGS) is increasingly being applied in clinical
laboratories for unbiased culture-independent diagnosis. Whether it can be a next routine …