[HTML][HTML] Machine learning for the prediction of sepsis: a systematic review and meta-analysis of diagnostic test accuracy

LM Fleuren, TLT Klausch, CL Zwager… - Intensive care …, 2020 - Springer
Purpose Early clinical recognition of sepsis can be challenging. With the advancement of
machine learning, promising real-time models to predict sepsis have emerged. We …

[HTML][HTML] 2023 update on sepsis and septic shock in adult patients: management in the emergency department

M Guarino, B Perna, AE Cesaro, M Maritati… - Journal of clinical …, 2023 - mdpi.com
Background: Sepsis/septic shock is a life-threatening and time-dependent condition that
requires timely management to reduce mortality. This review aims to update physicians with …

[HTML][HTML] Prospective, multi-site study of patient outcomes after implementation of the TREWS machine learning-based early warning system for sepsis

R Adams, KE Henry, A Sridharan, H Soleimani… - Nature medicine, 2022 - nature.com
Early recognition and treatment of sepsis are linked to improved patient outcomes. Machine
learning-based early warning systems may reduce the time to recognition, but few systems …

Surviving sepsis campaign: international guidelines for management of sepsis and septic shock 2021

L Evans, A Rhodes, W Alhazzani, M Antonelli… - Critical care …, 2021 - journals.lww.com
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to
infection (1). Sepsis and septic shock are major healthcare problems, impacting millions of …

[HTML][HTML] Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global Burden of Disease Study

KE Rudd, SC Johnson, KM Agesa, KA Shackelford… - The Lancet, 2020 - thelancet.com
Background Sepsis is life-threatening organ dysfunction due to a dysregulated host
response to infection. It is considered a major cause of health loss, but data for the global …

[HTML][HTML] Epidemiology and costs of sepsis in the United States—an analysis based on timing of diagnosis and severity level

CJ Paoli, MA Reynolds, M Sinha, M Gitlin… - Critical care …, 2018 - journals.lww.com
Objectives: To characterize the current burden, outcomes, and costs of managing sepsis
patients in US hospitals. Design: A retrospective observational study was conducted using …

Factors driving provider adoption of the TREWS machine learning-based early warning system and its effects on sepsis treatment timing

KE Henry, R Adams, C Parent, H Soleimani… - Nature medicine, 2022 - nature.com
Abstract Machine learning-based clinical decision support tools for sepsis create
opportunities to identify at-risk patients and initiate treatments at early time points, which is …

[HTML][HTML] Early prediction of sepsis from clinical data: the PhysioNet/Computing in Cardiology Challenge 2019

MA Reyna, CS Josef, R Jeter… - Critical care …, 2020 - journals.lww.com
Objectives: Sepsis is a major public health concern with significant morbidity, mortality, and
healthcare expenses. Early detection and antibiotic treatment of sepsis improve outcomes …

[HTML][HTML] Frequency and mortality of septic shock in Europe and North America: a systematic review and meta-analysis

JL Vincent, G Jones, S David, E Olariu, KK Cadwell - Critical care, 2019 - Springer
Background Septic shock is the most severe form of sepsis, in which profound underlying
abnormalities in circulatory and cellular/metabolic parameters lead to substantially …

Time to treatment and mortality during mandated emergency care for sepsis

CW Seymour, F Gesten, HC Prescott… - … England Journal of …, 2017 - Mass Medical Soc
Background In 2013, New York began requiring hospitals to follow protocols for the early
identification and treatment of sepsis. However, there is controversy about whether more …