Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …

Histone side chains are post-translationally modified at multiple sites, including at Lys36 on
histone H3 (H3K36). Several enzymes from yeast and humans, including the …

Post-translational modifications of histones by protein methyltransferases (PMTs) and
histone demethylases (KDMs) play an important role in the regulation of gene expression …

Abnormal epigenetic regulation has been implicated in oncogenesis. We report here the
identification of somatic mutations by exome sequencing in acute monocytic leukemia, the …

Nuclear receptor-binding SET-domain protein 1 (NSD1), a methyltransferase that catalyzes
H3K36me2, is essential for mammalian development and is frequently dysregulated in …

SET domain-containing proteins belong to a group of enzymes named after a common
domain that utilizes the cofactor S-adenosyl-L-methionine (SAM) to achieve methylation of …

NUP98 fusion proteins cause leukemia via unknown molecular mechanisms. All NUP98
fusion proteins share an intrinsically disordered region (IDR) in the NUP98 N terminus …

Sotos syndrome (SS) represents an important human model system for the study of
epigenetic regulation; it is an overgrowth/intellectual disability syndrome caused by …

The nuclear receptor–binding SET Domain (NSD) family of histone H3 lysine 36
methyltransferases is comprised of NSD1, NSD2 (MMSET/WHSC1), and NSD3 (WHSC1L1) …

Learning triggers alterations in gene transcription in brain regions such as the hippocampus
and the entorhinal cortex (EC) that are necessary for long-term memory (LTM) formation …