The physiological roles of tau and Aβ: implications for Alzheimer's disease pathology and therapeutics

SA Kent, TL Spires-Jones, CS Durrant - Acta neuropathologica, 2020 - Springer
Tau and amyloid beta (Aβ) are the prime suspects for driving pathology in Alzheimer's
disease (AD) and, as such, have become the focus of therapeutic development. Recent …

BACE1: More than just a β‐secretase

HA Taylor, L Przemylska, EM Clavane… - Obesity …, 2022 - Wiley Online Library
Summary β‐site amyloid precursor protein cleaving enzyme‐1 (BACE1) research has
historically focused on its actions as the β‐secretase responsible for the production of β …

The emerging roles of the β-secretase BACE1 and the long non-coding RNA BACE1-AS in human diseases: a focus on neurodegenerative diseases and cancer

A Sayad, S Najafi, BM Hussen, ST Abdullah… - Frontiers in Aging …, 2022 - frontiersin.org
The β-Secretase (BACE1) is widely studied to be particularly involved in amyloid deposition,
a process known as the pathogenic pathway in neurodegenerative diseases. Therefore …

Inverse molecular docking elucidating the anticarcinogenic potential of the hop natural product xanthohumol and its metabolites

K Kores, Z Kolenc, V Furlan, U Bren - Foods, 2022 - mdpi.com
Natural products from plants exert a promising potential to act as antioxidants,
antimicrobials, anti-inflammatory, and anticarcinogenic agents. Xanthohumol, a natural …

Celf family proteins in cancer: Highlights on the rna-binding protein/noncoding rna regulatory axis

M Nasiri-Aghdam, TC Garcia-Garduño… - International journal of …, 2021 - mdpi.com
Post-transcriptional modifications to coding and non-coding RNAs are unquestionably a
pivotal way in which human mRNA and protein diversity can influence the different phases …

Identification and Validation of the lncRNA BACE1‐AS as Immune‐Related Influencing Factor in Tumorigenesis following Pan‐Carcinoma Analysis

M Wang, D Chen, Y Xu, M Qiu… - Journal of Immunology …, 2021 - Wiley Online Library
Background. The lncRNA BACE1‐AS was identified as a plasma molecular marker in the
early diagnosis of Alzheimer's disease, but its role in tumors remains poorly defined …

LncRNA BACE1-AS promotes the progression of osteosarcoma through miR-762/SOX7 axis

C Wang, T Zhang, L Yang, X Na, Y Qu - Molecular Biology Reports, 2022 - Springer
Background Osteosarcoma (OS) is a rare malignant primary tumor of mesenchymal origin
affecting bone that occurs in adolescents and children. LncRNAs are important regulators of …

Measuring functional similarity of lncRNAs based on variable K-mer profiles of nucleotide sequences

Z Teng, L Shi, H Yu, C Wu, Z Tian - Methods, 2023 - Elsevier
Long non-coding RNAs are a class of essential non-coding RNAs with a length of more than
200 nts. Recent studies have indicated that lncRNAs have various complex regulatory …

The Reticulon-4 3-bp Deletion/Insertion Polymorphism Is Associated with Structural mRNA Changes and the Risk of Breast Cancer: A Population-Based Case …

P Pourzand, F Tabasi, F Fayazbakhsh, S Sarhadi… - Life, 2023 - mdpi.com
Breast cancer (BC) is a complex disease caused by molecular events that disrupt cellular
survival and death. Discovering novel biomarkers is still required to better understand and …

Bioinformatic analysis reveals the molecular targets of tangeretin in overcoming the resistance of breast cancer to tamoxifen

A Hermawan, H Putri, M Ikawati - Gene Reports, 2020 - Elsevier
The positive outcome of tamoxifen is reduced because of the emergence of intrinsic and
acquired resistance that triggers relapse and metastasis; as such, a combination therapy …