Disturbed cholesterol homeostasis plays critical roles in the development of multiple
diseases, such as cardiovascular diseases (CVD), neurodegenerative diseases and …

Lysophosphatidylcholine (LPC) is increasingly recognized as a key marker/factor positively
associated with cardiovascular and neurodegenerative diseases. However, findings from …

Low high-density lipoprotein cholesterol (HDL-C) characterizes an atherogenic dyslipidemia
that reflects adverse lifestyle choices, impaired metabolism, and increased cardiovascular …

Genome sequencing and gene-based therapies appear poised to advance the
management of rare lipoprotein disorders and associated dyslipidaemias. However, in …

Atherosclerosis, the pathological basis of most cardiovascular disease (CVD), is closely
associated with cholesterol accumulation in the arterial intima. Excessive cholesterol is …

Epidemiologic studies detected an inverse relationship between HDL (high-density
lipoprotein) cholesterol (HDL-C) levels and atherosclerotic cardiovascular disease …

In Japan, a super-aged society, deaths from atherosclerotic cardiovascular disease
(ASCVD), especially cardiac diseases including coronary artery disease (CAD) such as …

Through seven decades the inverse association between HDL cholesterol concentrations
and risk of atherosclerotic cardiovascular disease (ASCVD) has been observed in case …

Lecithin: cholesterol acyltransferase (LCAT) is the only enzyme in plasma which is able to
esterify cholesterol and boost cholesterol esterify with phospholipid-derived acyl chains. In …

Familial LCAT deficiency is a rare disease, with serious clinical manifestations, which can
occur in the first decades of life, and presently with no cure. The timely diagnosis in carriers …