Signal generation techniques for visual detection of analytes have received a great deal of
attention in various sensing fields. These approaches are considered to be advantageous …

Fanconi anaemia (FA) is a genetic disorder that is characterized by bone marrow failure
(BMF), developmental abnormalities and predisposition to cancer. Together with other …

Homologous recombination (HR) is a major pathway for the repair of DNA double-strand
breaks in mammalian cells, the defining step of which is homologous strand exchange …

Metal nanoclusters, composed of several to a few hundred metal atoms, have received
worldwide attention due to their extraordinary physical and chemical characteristics …

Whole-genome and centrosome duplication as a consequence of cytokinesis failure can
drive tumorigenesis in experimental model systems. However, whether cytokinesis failure is …

The proteins encoded by the two major breast cancer susceptibility genes, BRCA1 and
BRCA2, work in a common pathway of genome protection. However, the two proteins work …

Germ-line and somatic mutations in genes that promote homology-directed repair (HDR),
especially BRCA1 and BRCA2, are frequently observed in several cancers, in particular …

The mitotic checkpoint is a major cell cycle control mechanism that guards against
chromosome missegregation and the subsequent production of aneuploid daughter cells …

Cells with loss of BRCA2 function are defective in homologous recombination (HR) and are
highly sensitive to inhibitors of poly (ADP-ribose) polymerase (PARP),, which provides the …

Germline mutations in BRCA1 and BRCA2 predispose to common human malignancies,
most notably tumors of the breast and ovaries. The proteins encoded by these genes have …