The AT-rich interacting domain‑containing protein 1A gene (ARID1A) encodes ARID1A, a
member of the SWI/SNF chromatin remodeling complex. Mutation of ARID1A induces …

Biomarker-driven targeted therapies are lacking for head and neck squamous cell
carcinoma (HNSCC), which is common and lethal. Efforts to develop such therapies are …

Mutational signature analysis is commonly performed in cancer genomic studies. Here, we
present SigProfilerExtractor, an automated tool for de novo extraction of mutational …

Notch signaling represents a key mechanism mediating cancer metastasis and stemness.
To understand how Notch signaling is overactivated to couple tumor metastasis and self …

Abstract Dickkopf-1 (Dkk1) is a secretory antagonist of the classical Wnt signaling pathway.
Many studies have reported that Dkk1 is abnormally expressed in tumor cells, and abnormal …

Objectives Oesophageal squamous cell carcinoma (OSCC) and adenocarcinoma (OAC) are
distinct cancers in terms of a number of clinical and epidemiological characteristics …

Objective While oesophageal squamous cell carcinoma remains infrequent in Western
populations, the incidence of oesophageal adenocarcinoma (EAC) has increased sixfold to …

Lung cancer is one of the most common causes of cancer-related death in the world. The
large number of lung cancer cases is non-small cell lung cancer (NSCLC), which …

Background Carcinoma of the oral tongue (OTSCC) is the most common malignancy of the
oral cavity, characterized by frequent recurrence and poor survival. The last three decades …

Disruption of NOTCH1 signaling was recently discovered in head and neck cancer. This
study aims to evaluate NOTCH1 alterations in the progression of oral squamous cell …