The primary cilium is an antenna-like organelle assembled on most types of quiescent and
differentiated mammalian cells. This immotile structure is essential for interpreting …

The primary cilium is a ubiquitous microtubule-based organelle that senses external
environment and modulates diverse signaling pathways in different cell types and tissues …

Centrioles are vital cellular structures that form centrosomes and cilia. The formation and
function of cilia depends on a set of centriole's distal appendages. In this study, we use …

Multiple myeloma (MM) is an incurable plasma cell malignancy in the bone marrow
characterized by chromosome instability (CIN), which contributes to the acquisition of …

The NLR family pyrin domain containing 3 (NLRP3) inflammasome is one of the best-
characterized inflammasomes in humans and other mammals. However, knowledge about …

Infertility affects 10% of reproductive-age women and is extremely heterogeneous in
etiology. The genetic contribution to female infertility is incompletely understood, and …

Background Multiple myeloma (MM) is still incurable and characterized by clonal expansion
of plasma cells in the bone marrow (BM). Therefore, effective therapeutic interventions must …

Subdistal appendages (sDAPs) are centriolar elements that are observed proximal to the
distal appendages (DAPs) in vertebrates. Despite the obvious presence of sDAPs, structural …

Centrosomes are the major microtubule-organizing centers in animals and play fundamental
roles in many cellular processes. Understanding how their composition varies across …

Centrioles are microtubule-based structures in eukaryotic cells. From organizing the
microtubule cytoskeleton during interphase to focusing the mitotic spindle during mitosis …