Viral pathogens often induce strong effector CD4+ T cell responses that are best known for
their ability to help B cell and CD8+ T cell responses. However, recent studies have …

Gammaherpesviruses are lymphotropic viruses that are associated with the development of
lymphoproliferative diseases, lymphomas, as well as other nonlymphoid cancers. Most …

Major histocompatibility complex (MHC) class II molecules present products of lysosomal
proteolysis to CD4+ T cells. Although extracellular antigen uptake is considered to be the …

Although studies have established that innate and adaptive immune responses are
important in controlling West Nile virus (WNV) infection, the function of CD4+ T lymphocytes …

The two major subsets of peripheral T cells are classically divided into the CD4+ T helper
cells and the cytotoxic CD8+ T cell lineage. However, the appearance of some effector …

A conserved herpesviral kinase, designated ORF36 in murine γ-herpesvirus 68 (MHV-68),
plays multiple vital roles in the viral life cycle. Here, we show by screening mutant viruses …

During thymic development, thymocytes expressing a T cell receptor consisting of an alpha
and beta chain (TCRαβ), commit to either the cytotoxic-or T helper-lineage fate. This lineage …

Autophagy delivers cytoplasmic constituents for lysosomal degradation. Recent studies
have demonstrated that this pathway mediates resistance to pathogens and is targeted for …

Alpha/beta interferon (IFN-α/β) protects the host from virus infection by inhibition of lytic virus
replication in infected cells and modulation of the antiviral cell-mediated immune response …

CD4+ T cells are classically thought to orchestrate adaptive immune responses. But recent
studies demonstrate that they can also kill infected cells directly. A new paper shows that …