Molecular mechanism of azithromycin resistance among typhoidal Salmonella strains in Bangladesh identified through passive pediatric surveillance
Background With the rise in fluoroquinolone-resistant Salmonella Typhi and the recent
emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available …
emergence of ceftriaxone resistance, azithromycin is one of the last oral drugs available …
Parallel evolution of tobramycin resistance across species and environments
Different species exposed to a common stress may adapt by mutations in shared pathways
or in unique systems, depending on how past environments have molded their genomes …
or in unique systems, depending on how past environments have molded their genomes …
MarA, RamA, and SoxS as mediators of the stress response: survival at a cost
To survive and adapt to changing environments, bacteria have evolved mechanisms to
express appropriate genes at appropriate times. Exposure to antimicrobials triggers a global …
express appropriate genes at appropriate times. Exposure to antimicrobials triggers a global …
Cryo-EM Structure and Molecular Dynamics Analysis of the Fluoroquinolone Resistant Mutant of the AcrB Transporter from Salmonella
RM Johnson, C Fais, M Parmar, H Cheruvara… - Microorganisms, 2020 - mdpi.com
Salmonella is an important genus of Gram-negative pathogens, treatment of which has
become problematic due to increases in antimicrobial resistance. This is partly attributable to …
become problematic due to increases in antimicrobial resistance. This is partly attributable to …
Massively parallel transposon mutagenesis identifies temporally essential genes for biofilm formation in Escherichia coli
Biofilms complete a life cycle where cells aggregate, grow and produce a structured
community before dispersing to colonize new environments. Progression through this life …
community before dispersing to colonize new environments. Progression through this life …
Functionally distinct mutations within AcrB underpin antibiotic resistance in different lifestyles
Antibiotic resistance is a pressing healthcare challenge and is mediated by various
mechanisms, including the active export of drugs via multidrug efflux systems, which prevent …
mechanisms, including the active export of drugs via multidrug efflux systems, which prevent …
From acute to persistent infection: revealing phylogenomic variations in Salmonella Agona
Salmonella enterica serovar Agona (S. Agona) has been increasingly recognised as a
prominent cause of gastroenteritis. This serovar is a strong biofilm former that can undergo …
prominent cause of gastroenteritis. This serovar is a strong biofilm former that can undergo …
Donor plasmids for phenotypically neutral chromosomal gene insertions in Enterobacteriaceae
Recombineering using bacteriophage lambda Red recombinase (λ-Red) uses homologous
recombination to manipulate bacterial genomes and is commonly applied to disrupt genes …
recombination to manipulate bacterial genomes and is commonly applied to disrupt genes …
Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella
E Trampari, C Zhang, K Gotts, GM Savva… - Microbiology …, 2022 - Am Soc Microbiol
Cephalosporins are important beta lactam antibiotics, but resistance can be mediated by
various mechanisms including production of beta lactamase enzymes, changes in …
various mechanisms including production of beta lactamase enzymes, changes in …
Experimental evolution to identify undescribed mechanisms of resistance to a novel cationic peptide antibiotic
A Santos-Lopez, MJ Fritz, JB Lombardo, AHP Burr… - bioRxiv, 2020 - biorxiv.org
A key strategy for resolving the antibiotic resistance crisis is the development of new drugs
with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also …
with antimicrobial properties. The engineered cationic antimicrobial peptide WLBU2 (also …