MicroRNAs (miRNAs) are small non-coding RNA molecules that regulate gene expression.
They have important roles during kidney development, homeostasis and disease. In …

More than two dozen types of potassium channels, with different biophysical and regulatory
properties, are expressed in the kidney, influencing renal function in many important ways …

For the past two decades several scholarly reviews have appeared on the inwardly rectifying
potassium (Kir) channels. We would like to highlight two efforts in particular, which have …

Activation of the renin–angiotensin–aldosterone system (RAAS) plays an important
pathophysiological role in hypertension. Increased mRNA levels of the angiotensinogen …

Small non-coding RNAs (microRNAs) are important regulators of gene expression that
modulate many physiological processes; however, their role in regulating intracellular …

The final steps in the Renin‐Angiotensin‐Aldosterone signaling System (RAAS) involve
binding of the corticosteroid hormone, aldosterone to its mineralocorticoid receptor (MR) …

The mineralocorticoid hormone aldosterone is released by the adrenal glands in a
homeostatic mechanism to regulate blood volume. The long-term renal action of aldosterone …

The epithelial sodium channel (ENaC) is expressed in the epithelial cells of the distal
convoluted tubules, connecting tubules, and cortical collecting duct (CCD) in the kidney …

The Mineralocorticoid Receptor (MR) mediates the sodium-retaining action of aldosterone in
the distal nephron, but mechanisms regulating MR expression are still poorly understood …

Diabetic Kidney Disease (DKD) is a significant complication of diabetes and primary cause
of end-stage renal disease globally. The exact mechanisms underlying DKD remain poorly …