DNA methylation abnormalities are regarded as critical event for cancer initiation and
development. Tumor-associated genes encompassing aberrant DNA methylation alterations …

Traditionally, it has been believed that inheritance is driven as phenotypic variations
resulting from changes in DNA sequence. However, this paradigm has been challenged and …

Epigenome editing is a promising technology, potentially allowing the stable reprogramming
of gene expression profiles without alteration of the DNA sequence. Targeted DNA …

A set of> 300 nonredundant high-resolution RNA–protein complexes were rigorously
searched for π-contacts between an amino acid side chain (W, H, F, Y, R, E and D) and an …

DNA methylation plays a pivotal role in various biological processes and is highly related to
multiple diseases. The exact functions of DNA methylation are still puzzling due to its …

Targeted DNA methylation is a technique that aims to methylate cytosines in selected
genomic loci. In the most widely used approach a CG-specific DNA methyltransferase …

The study of epigenetics has greatly benefited from the development and application of
various chemical biology approaches. In this review, we highlight the key targets for …

Background Epigenetic variation is mediated by epigenetic marks such as DNA methylation
occurring in all cytosine contexts in plants. CG methylation plays a critical role in silencing …

Many research questions benefit from molecular dynamics simulations to observe the
motions and conformations of molecules over time, which rely on force fields that describe …

Multicellular organism development requires intricate spatial and temporal coordination of
complex and dynamic gene regulatory programs. Until recently, few robust technologies …