The biochemical indicators of tumor microenvironment (TME) that are different from normal
tissues provide the possibility for constructing intelligent drug delivery systems (DDSs) …

Polysaccharides contain different functional groups (such as hydroxyl, amino, carboxylic
acid, aldehydes) that make them ideal for conjugation. They are biodegradable …

The oral route has long been recognized as the most preferred route for drug delivery as it
offers high patient compliance and requires minimal expertise. Unlike small molecule drugs …

Polysaccharides are ideal candidates for drug delivery and biomedical applications as they
are easily obtained from natural sources. Furthermore, they can be subjected to a wide …

Now-a-days, the polysaccharides are extensively employed for the delivery of small-
molecule drugs ascribed to their excellent biocompatibility, biodegradability and …

Podophyllotoxin (PPT) exhibited significant activity against P-glycoprotein mediated
multidrug resistant (MDR) tumor cell lines; however, due to its poor solubility and high …

Paclitaxel, a taxane, is a cytotoxic chemotherapeutic agent that targets microtubules. It has
become a front-line therapy for a broad range of malignancies, including lung, breast …

Fluorouracil is an anticancer drug with a short biological half-life. This study aimed to
develop oral sustained-release nano-formulations of 5-Fluorouracil. 5-Fluorouracil …

A prodrug gelation strategy was developed for the sustained and dual stimuli-response
release of doxorubicin hydrochloride (DOX· HCl), a commonly used anticancer drug. For this …

A polymeric prodrug of cisplatin (CP) with simple chemical structure was synthesized based
on pullulan and its therapeutic effects on human hepatocellular carcinoma (HCC) were …