Theoretical Design of Paradoxical Signaling-Based Synthetic Population Control Circuit in E. coli

MN Mayalu, RM Murray - bioRxiv, 2020 - biorxiv.org
We have developed a mathematical framework to analyze the cooperative control of cell
population homeostasis via paradoxical signaling in synthetic contexts. Paradoxical …

Model-guided Design of Biological Controller for Septic Wound Healing Regulation

LN Green, P Naghshnejad, D Dankwa, X Tang - bioRxiv, 2023 - biorxiv.org
Immune response is critical in septic wound healing. The aberrant and imbalanced signaling
dynamics primarily cause a dysfunctional innate immune response, exacerbating pathogen …